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    RTC5 Rtc5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854285, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RTC5
    Official Full Name
    Rtc5p
    Primary source
    SGD:S000005644
    Locus tag
    YOR118W
    See related
    AllianceGenome:SGD:S000005644; FungiDB:YOR118W; VEuPathDB:YOR118W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Acts upstream of or within protein-containing complex disassembly. Located in fungal-type vacuole membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RTC5 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (546857..548560)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase III core subunit RPO31 Neighboring gene proteasome regulatory particle base subunit RPT5 Neighboring gene protein kinase RIO1 Neighboring gene glycerol 2-dehydrogenase (NADP(+)) GCY1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast TLDc domain proteins regulate assembly state and subcellular localization of the V-ATPase. Klössel S, et al. EMBO J, 2024 May. PMID 38589611, Free PMC Article
    2. Yeast Nst1 is a novel component of P-bodies and is a specific suppressor of proteasome base assembly defects. Cheng CL, et al. Mol Biol Cell, 2021 Oct 1. PMID 34347506, Free PMC Article
    3. Genetic interaction network of the Saccharomyces cerevisiae type 1 phosphatase Glc7. Logan MR, et al. BMC Genomics, 2008 Jul 15. PMID 18627629, Free PMC Article
    4. Assembly of Saccharomyces cerevisiae 60S ribosomal subunits: role of factors required for 27S pre-rRNA processing. Sahasranaman A, et al. EMBO J, 2011 Sep 16. PMID 21926967, Free PMC Article
    5. Sulfate assimilation mediates tellurite reduction and toxicity in Saccharomyces cerevisiae. Ottosson LG, et al. Eukaryot Cell, 2010 Oct. PMID 20675578, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein-containing complex disassembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rtc5p
    NP_014761.1
    • Protein that regulates the vacuolar V-ATPase; regulates the assembly state of the V-ATPase holoenzyme, promoting complex disassembly, and counteracting the function of the RAVE complex; interacts with V-ATPase subunits; vacuolar membrane localization requires N-myristoylation and an assembled V-ATPase; GFP-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity; member of a conserved family of TLDc domain proteins found in eukaryotes

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      546857..548560
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183537.1 → NP_014761.1  TPA: Rtc5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014761.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZNW6, B3LJG1, C7GML8, C8ZI80, D6W2H7, Q12108
      UniProtKB/TrEMBL
      G2WMZ4, N1NVS7
      Conserved Domains (1) summary
      pfam07534
      Location:355 → 514
      TLD
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12108.1

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