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    Taf12 TATA-box binding protein associated factor 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 682902, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Taf12provided by RGD
    Official Full Name
    TATA-box binding protein associated factor 12provided by RGD
    Primary source
    RGD:1592841
    See related
    EnsemblRapid:ENSRNOG00000048288 AllianceGenome:RGD:1592841
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including DNA-binding transcription factor binding activity; TBP-class protein binding activity; and transcription coactivator activity. Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly; mRNA transcription by RNA polymerase II; and positive regulation of transcription initiation by RNA polymerase II. Predicted to be part of SAGA complex; transcription factor TFIID complex; and transcription factor TFTC complex. Predicted to be active in nucleus. Orthologous to human TAF12 (TATA-box binding protein associated factor 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 57.5), Muscle (RPKM 56.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Taf12 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (149756826..149772886)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (144472816..144490299)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (150459701..150476521)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene glucocorticoid modulatory element binding protein 1 Neighboring gene U11 spliceosomal RNA Neighboring gene uncharacterized LOC120102992 Neighboring gene small nucleolar RNA SNORA16B/SNORA16A family Neighboring gene RAB42, member RAS oncogene family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A functional interaction between ATF7 and TAF12 that is modulated by TAF4. Hamard PJ, et al. Oncogene, 2005 May 12. PMID 15735663
    2. Sumoylation delays the ATF7 transcription factor subcellular localization and inhibits its transcriptional activity. Hamard PJ, et al. Nucleic Acids Res, 2007. PMID 17264123, Free PMC Article
    3. Core promoter binding by histone-like TAF complexes. Shao H, et al. Mol Cell Biol, 2005 Jan. PMID 15601843, Free PMC Article
    4. Structural bioinformatics of the general transcription factor TFIID. Malkowska M, et al. Biochimie, 2013 Apr. PMID 23146842
    5. TFIIB-related factors in RNA polymerase I transcription. Knutson BA, et al. Biochim Biophys Acta, 2013 Mar-Apr. PMID 22960599, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to RNA polymerase II general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables TBP-class protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA polymerase II preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA polymerase II preinitiation complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription initiation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of SAGA complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFTC complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcription initiation factor TFIID subunit 12
    Names
    TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001115036.1 → NP_001108508.1  transcription initiation factor TFIID subunit 12

      See identical proteins and their annotated locations for NP_001108508.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473968
      UniProtKB/TrEMBL
      B0BMY3, M0R9S2
      Conserved Domains (1) summary
      cd07981
      Location:58 → 126
      TAF12; TATA Binding Protein (TBP) Associated Factor 12

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      149756826..149772886
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006239067.5 → XP_006239129.1  transcription initiation factor TFIID subunit 12 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JZ70, A0A8I6ABQ9
      Related
      ENSRNOP00000070933.1, ENSRNOT00000081681.3
      Conserved Domains (1) summary
      cd07981
      Location:110 → 178
      TAF12; TATA Binding Protein (TBP) Associated Factor 12

    2. XM_006239068.5 → XP_006239130.1  transcription initiation factor TFIID subunit 12 isoform X2

      See identical proteins and their annotated locations for XP_006239130.1

      UniProtKB/TrEMBL
      B0BMY3, M0R9S2
      Conserved Domains (1) summary
      cd07981
      Location:58 → 126
      TAF12; TATA Binding Protein (TBP) Associated Factor 12
    Nucleotide Protein Strain
    Heading Accession and Version

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