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    Arpp19 cAMP-regulated phosphoprotein 19 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60336, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arpp19provided by RGD
    Official Full Name
    cAMP-regulated phosphoprotein 19provided by RGD
    Primary source
    RGD:71054
    See related
    EnsemblRapid:ENSRNOG00000063103 AllianceGenome:RGD:71054
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Arpp-19
    Summary
    Predicted to enable several functions, including potassium channel regulator activity; protein phosphatase 2A binding activity; and protein phosphatase inhibitor activity. Involved in G protein-coupled dopamine receptor signaling pathway and positive regulation of Ras protein signal transduction. Located in cytosol; dendrite; and synapse. Orthologous to human ARPP19 (cAMP regulated phosphoprotein 19). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 502.0), Lung (RPKM 293.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arpp19 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (84660166..84683012)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (75779640..75802474)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (81949577..81972054)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene one cut homeobox 1 Neighboring gene atos homolog A Neighboring gene myosin VA Neighboring gene small nucleolar RNA U3 Neighboring gene myosin VC

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of ARPP-16/19 in rat denervated skeletal muscle. Yoshikawa A, et al. J Biochem, 2003 Jul. PMID 12944371
    2. Nerve growth factor controls GAP-43 mRNA stability via the phosphoprotein ARPP-19. Irwin N, et al. Proc Natl Acad Sci U S A, 2002 Sep 17. PMID 12221279, Free PMC Article
    3. Differential expression of ARPP-16 and ARPP-19, two highly related cAMP-regulated phosphoproteins, one of which is specifically associated with dopamine-innervated brain regions. Girault JA, et al. J Neurosci, 1990 Apr. PMID 2158525, Free PMC Article
    4. ARPP-16/ARPP-19: a highly conserved family of cAMP-regulated phosphoproteins. Dulubova I, et al. J Neurochem, 2001 Apr. PMID 11279279
    5. Human alpha-endosulfine, a possible regulator of sulfonylurea-sensitive KATP channel: molecular cloning, expression and biological properties. Heron L, et al. Proc Natl Acad Sci U S A, 1998 Jul 7. PMID 9653196, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ARPP-19 is an important link between NGF signaling and post-transcriptional control of neuronal gene expression.
      Title: Nerve growth factor controls GAP-43 mRNA stability via the phosphoprotein ARPP-19.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables potassium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase 2A binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase 2A binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein phosphatase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled dopamine receptor signaling pathway IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in G2/M transition of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of Ras protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cAMP-regulated phosphoprotein 19
    Names
    cyclic AMP phosphoprotein, 19 kDa
    cyclic AMP phosphoprotein, 19kD

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395717.1 → NP_001382646.1  cAMP-regulated phosphoprotein 19 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      JAXUCZ010000008

    2. NM_001395718.1 → NP_001382647.1  cAMP-regulated phosphoprotein 19 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q712U5
      UniProtKB/TrEMBL
      A0A8I6A898, A6I1B0
      Conserved Domains (1) summary
      pfam04667
      Location:28 → 103
      Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

    3. NM_001395719.1 → NP_001382648.1  cAMP-regulated phosphoprotein 19 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q712U5
      UniProtKB/TrEMBL
      A0A8I6A898, A6I1B0
      Related
      ENSRNOP00000109754.1, ENSRNOT00000153864.1
      Conserved Domains (1) summary
      pfam04667
      Location:28 → 103
      Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

    4. NM_031660.2 → NP_113848.1  cAMP-regulated phosphoprotein 19 isoform b

      See identical proteins and their annotated locations for NP_113848.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q712U5
      UniProtKB/TrEMBL
      A0A8I6A898, A6I1B0
      Conserved Domains (1) summary
      pfam04667
      Location:28 → 103
      Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      84660166..84683012
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266060.1 → XP_063122130.1  cAMP-regulated phosphoprotein 19 isoform X3

    2. XM_063266062.1 → XP_063122132.1  cAMP-regulated phosphoprotein 19 isoform X4

    3. XM_063266059.1 → XP_063122129.1  cAMP-regulated phosphoprotein 19 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A898, A6I1A8

    4. XM_039082046.2 → XP_038937974.2  cAMP-regulated phosphoprotein 19 isoform X1

      Related
      ENSRNOP00000087184.3, ENSRNOT00000098678.3

    5. XM_063266061.1 → XP_063122131.1  cAMP-regulated phosphoprotein 19 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q712U5.3 GenPept UniProtKB/Swiss-Prot:Q712U5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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