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    Cbarp CACN subunit beta associated regulatory protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314622, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cbarpprovided by RGD
    Official Full Name
    CACN subunit beta associated regulatory proteinprovided by RGD
    Primary source
    RGD:1307185
    See related
    EnsemblRapid:ENSRNOG00000024349 AllianceGenome:RGD:1307185
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dos
    Summary
    Predicted to enable transmembrane transporter binding activity. Involved in negative regulation of voltage-gated calcium channel activity. Located in secretory granule. Orthologous to human CBARP (CACN subunit beta associated regulatory protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 124.3), Adrenal (RPKM 29.2) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cbarp in Genome Data Viewer
    Location:
    7q11
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10217314..10225855)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9566637..9575204)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12433422..12441048)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene cold inducible RNA binding protein Neighboring gene midnolin Neighboring gene ATP synthase F1 subunit delta Neighboring gene serine/threonine kinase 11 Neighboring gene uncharacterized LOC134479811 Neighboring gene strawberry notch homolog 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. BARP suppresses voltage-gated calcium channel activity and Ca2+-evoked exocytosis. Béguin P, et al. J Cell Biol, 2014 Apr 28. PMID 24751537, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC189449

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of calcium ion-dependent exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of calcium ion-dependent exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of voltage-gated calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in secretory granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    voltage-dependent calcium channel beta subunit-associated regulatory protein
    Names
    CACN beta subunit associated regulatory protein
    calcium channel, voltage-dependent, beta subunit associated regulatory protein
    downstream of Stk11
    protein Dos

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108070.4 → NP_001101540.1  voltage-dependent calcium channel beta subunit-associated regulatory protein

      See identical proteins and their annotated locations for NP_001101540.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6K8Q7, B5DFH0

    2. NM_001388507.1 → NP_001375436.1  voltage-dependent calcium channel beta subunit-associated regulatory protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6K8Q7, B5DFH0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      10217314..10225855
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078984.2 → XP_038934912.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform X2

      UniProtKB/TrEMBL
      F1MAS1
      Related
      ENSRNOP00000057421.4, ENSRNOT00000060690.6

    2. XM_039078983.2 → XP_038934911.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform X1

    3. XM_039078985.2 → XP_038934913.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Research Materials
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