Rmnd5b required for meiotic nuclear division 5 homolog B [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Rmnd5bprovided by RGD
Full Name: required for meiotic nuclear division 5 homolog Bprovided by RGD
Primary source: RGD:1559511
See related: EnsemblRapid:ENSRNOG00000047396 AllianceGenome:RGD:1559511
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable metal ion binding activity and ubiquitin protein ligase activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be part of GID complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human RMND5B (required for meiotic nuclear division 5 homolog B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 108.0), Testes (RPKM 101.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (36382212..36394801, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (35881250..35892322, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (34979902..34990985, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D6S1560 (e-PCR), detects polymorphism
- UniSTS:464433

D6S1560 (e-PCR), detects polymorphism
- UniSTS:36947

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
contributes_to ubiquitin-protein transferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of GID complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: E3 ubiquitin-protein transferase RMND5B

Names: protein RMD5 homolog B

NP_001017473.1

EC 2.3.2.27

XP_006246267.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017473.1 → NP_001017473.1 E3 ubiquitin-protein transferase RMND5B

See identical proteins and their annotated locations for NP_001017473.1

Status: PROVISIONAL

Source sequence(s)

BC093386

UniProtKB/TrEMBL

Q566Q9

Related

ENSRNOP00000065529.1, ENSRNOT00000075555.4

Conserved Domains (2) summary

COG5109
Location:60 → 393

COG5109; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

pfam10607
Location:155 → 299

CLTH; CTLH/CRA C-terminal to LisH motif domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

36382212..36394801 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006246205.4 → XP_006246267.1 E3 ubiquitin-protein transferase RMND5B isoform X1

See identical proteins and their annotated locations for XP_006246267.1

UniProtKB/TrEMBL

Q566Q9

Conserved Domains (2) summary

COG5109
Location:60 → 393

COG5109; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

pfam10607
Location:155 → 299

CLTH; CTLH/CRA C-terminal to LisH motif domain