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    Rtfdc1 replication termination factor 2 domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296410, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rtfdc1provided by RGD
    Official Full Name
    replication termination factor 2 domain containing 1provided by RGD
    Primary source
    RGD:1311072
    See related
    EnsemblRapid:ENSRNOG00000005083 AllianceGenome:RGD:1311072
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RTF2; RGD1311072
    Summary
    Predicted to enable DNA binding activity. Predicted to be involved in cellular response to hydroxyurea and regulation of DNA stability. Predicted to be located in replication fork. Predicted to be active in nucleus. Orthologous to human RTF2 (replication termination factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 197.4), Heart (RPKM 176.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rtfdc1 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (181624798..181656104)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (161208005..161237687)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (170443895..170473456)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene cleavage stimulation factor subunit 1 Neighboring gene Cas scaffold protein family member 4 Neighboring gene glucosaminyl (N-acetyl) transferase family member 7 Neighboring gene uncharacterized LOC134486498 Neighboring gene family with sequence similarity 209

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Removal of RTF2 from Stalled Replisomes Promotes Maintenance of Genome Integrity. Kottemann MC, et al. Mol Cell, 2018 Jan 4. PMID 29290612, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124670

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to hydroxyurea ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to hydroxyurea ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitotic DNA replication termination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA stability ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in replication fork ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in replication fork ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    replication termination factor 2
    Names
    UPF0549 protein C20orf43 homolog
    protein RTF2 homolog
    replication termination factor 2 domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033890.1 → NP_001029062.1  replication termination factor 2

      See identical proteins and their annotated locations for NP_001029062.1

      Status: PROVISIONAL

      Source sequence(s)
      BC101880
      UniProtKB/Swiss-Prot
      Q3T1J8
      UniProtKB/TrEMBL
      A0A8L2Q2N4
      Conserved Domains (1) summary
      pfam04641
      Location:1 → 289
      Rtf2; Rtf2 RING-finger

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      181624798..181656104
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104652.2 → XP_038960580.1  replication termination factor 2 isoform X1

      Related
      ENSRNOP00000006884.5, ENSRNOT00000006884.7
      Conserved Domains (1) summary
      pfam04641
      Location:1 → 199
      Rtf2; Rtf2 RING-finger
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3T1J8.1 GenPept UniProtKB/Swiss-Prot:Q3T1J8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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