Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnj11provided by RGD
Official Full Name: potassium inwardly-rectifying channel, subfamily J, member 11provided by RGD
Primary source: RGD:69247
See related: EnsemblRapid:ENSRNOG00000021128 AllianceGenome:RGD:69247
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kir6.2
Summary: Enables several functions, including ankyrin binding activity; monoatomic cation transmembrane transporter activity; and transmembrane transporter binding activity. Involved in several processes, including cellular response to nicotine; potassium ion import across plasma membrane; and response to ischemia. Located in several cellular components, including axolemma; cell body fiber; and cytoplasmic vesicle. Part of inward rectifying potassium channel. Is active in glutamatergic synapse and presynaptic membrane. Biomarker of brain disease (multiple); glucose metabolism disease (multiple); hypertension; and sciatic neuropathy. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple). Orthologous to human KCNJ11 (potassium inwardly rectifying channel subfamily J member 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 327.7), Heart (RPKM 215.6) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (105727473..105731167, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (96591048..96594574, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (102103093..102107134, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our findings suggest that the NF-kappaB, p38 MAPK, and PKC signal pathways are partially involved in the upregulation of KATP subunits Kir6.2/SUR1 expression induced by Abeta1-42 cytotoxicity in neurons, which supports a potential theoretical basis of targeting these signal pathways in the treatment of Alzheimer's disease.
Title: Aβ1-42 increases the expression of neural KATP subunits Kir6.2/SUR1 via the NF-κB, p38 MAPK and PKC signal pathways in rat primary cholinergic neurons.
Up-regulation of the KATP channel accelerates repolarization and shortens action potential duration during stress and exercise.
Title: Effects of regular exercise on ventricular myocyte biomechanics and K(ATP) channel function.
Intricate interactions between TMD0, the loop following TMD0, and Kir6.2 near the proposed PIP2 binding site, and where ATP density is observed, suggest SUR1 may contribute to ATP and PIP2 binding to enhance Kir6.2 sensitivity to both.
Title: Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating.
The E23K variant of the KATP channel increased the susceptibility to ventricular arrhythmia under acute ischemia stress.
Title: The E23K variant of the Kir6.2 subunit of the ATP-sensitive potassium channel increases susceptibility to ventricular arrhythmia in response to ischemia in rats.
both Kir6.1(V65M) and Kir6.2(V64M) mutations essentially abolish high-affinity sensitivity to the KATP blocker glibenclamide in both intact cells and excised patches. This raises the possibility that, at least for some CS mutations, sulfonylurea therapy may not prove to be successful and highlights the need for detailed pharmacogenomic analyses of CS mutations.
Title: Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel.
Data show that sarcolemmal ATP-sensitive K+ (sarcKATP) channel mutant subunit Kir6.2AAA transfection inhibited the channel activity and significantly aggravated the apoptosis of myocytes induced by lipopolysaccharides (LPS).
Title: Sarcolemmal ATP-sensitive potassium channel protects cardiac myocytes against lipopolysaccharide-induced apoptosis.
Electrophysiological studies employing SUR2A/Kir6.2-expressing HEK cells showed that increasing endogenous or exogenous Phosphatidylinositol 4,5-bisphosphate diminished the inhibitory effect of Syn-1A on KATP currents.
Title: Phosphatidylinositol 4,5-biphosphate (PIP2) modulates syntaxin-1A binding to sulfonylurea receptor 2A to regulate cardiac ATP-sensitive potassium (KATP) channels.
Findings suggest that Kir6.2 expression in the spinal cord is reduced in bone cancer pain and activation of Kir6.2 at the spinal level reduces pain hypersensitivity associated with bone cancer pain
Title: Role of ATP-sensitive potassium channels in modulating nociception in rat model of bone cancer pain.
PIP2 affects islet beta-cell KATP channels not only by its actions on Kir6.2 but also by sequestering Syn-1A to modulate Syn-1A availability and its interactions with SUR1 on PM.
Title: Phosphatidylinositol 4,5-biphosphate (PIP2) modulates interaction of syntaxin-1A with sulfonylurea receptor 1 to regulate pancreatic β-cell ATP-sensitive potassium channels.
Kir6.2 plays a central role in ischemic preconditioning and calcium and mitochondrial homeostasis during stress, and the impact of decreasing channel number is deleterious to myocyte survival.
Title: Kir6.2 limits Ca(2+) overload and mitochondrial oscillations of ventricular myocytes in response to metabolic stress.

Submit: New GeneRIF Correction See all GeneRIFs (51)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC312732P1 (e-PCR)
- UniSTS:272909

RH130776 (e-PCR)
- UniSTS:214060

BE113377 (e-PCR)
- UniSTS:246655

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP-activated inward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-activated inward rectifier potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP-activated inward rectifier potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ATP-activated inward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables ATPase-coupled monoatomic cation transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables ankyrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables ankyrin binding	ISO Inferred from Sequence Orthology more info
enables heat shock protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables inward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within CAMKK-AMPK signaling cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within action potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to nicotine	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular response to nutrient levels	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within determination of adult lifespan	ISO Inferred from Sequence Orthology more info
involved_in glucose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in inorganic cation transmembrane transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in nervous system process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cation channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in potassium ion import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of monoatomic ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in response to ATP	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to ATP	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to ischemia	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to ischemia	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to resveratrol	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to stress	ISO Inferred from Sequence Orthology more info
involved_in response to testosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ventricular cardiac muscle tissue development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in T-tubule	IDA Inferred from Direct Assay more info	PubMed
located_in T-tubule	ISO Inferred from Sequence Orthology more info
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in axolemma	IDA Inferred from Direct Assay more info	PubMed
located_in cell body fiber	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in intercalated disc	IDA Inferred from Direct Assay more info	PubMed
part_of inward rectifying potassium channel	IDA Inferred from Direct Assay more info	PubMed
part_of inward rectifying potassium channel	ISO Inferred from Sequence Orthology more info
part_of inward rectifying potassium channel	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ATP-sensitive inward rectifier potassium channel 11

Names: BIR; inward rectifier K(+) channel Kir6.2; potassium channel, inwardly rectifying subfamily J member 11; potassium voltage-gated channel subfamily J member 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031358.3 → NP_112648.2 ATP-sensitive inward rectifier potassium channel 11

See identical proteins and their annotated locations for NP_112648.2

Status: VALIDATED

Source sequence(s)

AB043638, AW527189, BF565039, D61687, D86039

UniProtKB/Swiss-Prot

P70673, Q62906, Q9JM48

UniProtKB/TrEMBL

A6JBB1

Related

ENSRNOP00000028685.1, ENSRNOT00000028685.5

Conserved Domains (1) summary

pfam01007
Location:36 → 356

IRK; Inward rectifier potassium channel

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

105727473..105731167 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008759421.4 → XP_008757643.1 ATP-sensitive inward rectifier potassium channel 11 isoform X3

Conserved Domains (2) summary

pfam17655
Location:94 → 267

IRK_C; Inward rectifier potassium channel C-terminal domain

cl21560
Location:1 → 87

Ion_trans_2; Ion channel
XM_017589780.3 → XP_017445269.1 ATP-sensitive inward rectifier potassium channel 11 isoform X2

Conserved Domains (2) summary

pfam17655
Location:105 → 278

IRK_C; Inward rectifier potassium channel C-terminal domain

cl21560
Location:1 → 98

Ion_trans_2; Ion channel
XM_039092510.2 → XP_038948438.1 ATP-sensitive inward rectifier potassium channel 11 isoform X1

Conserved Domains (2) summary

pfam17655
Location:124 → 297

IRK_C; Inward rectifier potassium channel C-terminal domain

cl21560
Location:25 → 117

Ion_trans_2; Ion channel
XM_039092522.2 → XP_038948450.1 ATP-sensitive inward rectifier potassium channel 11 isoform X3

Conserved Domains (2) summary

pfam17655
Location:94 → 267

IRK_C; Inward rectifier potassium channel C-terminal domain

cl21560
Location:1 → 87

Ion_trans_2; Ion channel
XM_039092515.1 → XP_038948443.1 ATP-sensitive inward rectifier potassium channel 11 isoform X3

Conserved Domains (2) summary

pfam17655
Location:94 → 267

IRK_C; Inward rectifier potassium channel C-terminal domain

cl21560
Location:1 → 87

Ion_trans_2; Ion channel
XM_017589782.2 → XP_017445271.1 ATP-sensitive inward rectifier potassium channel 11 isoform X2

Conserved Domains (2) summary

pfam17655
Location:105 → 278

IRK_C; Inward rectifier potassium channel C-terminal domain

cl21560
Location:1 → 98

Ion_trans_2; Ion channel