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    RSC6 Rsc6p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850419, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RSC6
    Official Full Name
    Rsc6p
    Primary source
    SGD:S000000648
    Locus tag
    YCR052W
    See related
    AllianceGenome:SGD:S000000648; FungiDB:YCR052W; VEuPathDB:YCR052W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables structural molecule activity. Involved in nucleosome disassembly and positive regulation of transcription elongation by RNA polymerase II. Part of RSC-type complex. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 11. Orthologous to human SMARCD1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1); SMARCD2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2); and SMARCD3 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RSC6 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (214994..216445)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene sterol acyltransferase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene threonine synthase THR4 Neighboring gene Ctr86p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sfh1p, a component of a novel chromatin-remodeling complex, is required for cell cycle progression. Cao Y, et al. Mol Cell Biol, 1997 Jun. PMID 9154831, Free PMC Article
    2. Direct interaction between Rsc6 and Rsc8/Swh3,two proteins that are conserved in SWI/SNF-related complexes. Treich I, et al. Nucleic Acids Res, 1998 Aug 15. PMID 9685490, Free PMC Article
    3. The RSC chromatin remodelling enzyme has a unique role in directing the accurate positioning of nucleosomes. Wippo CJ, et al. EMBO J, 2011 Apr 6. PMID 21343911, Free PMC Article
    4. RSC, an essential, abundant chromatin-remodeling complex. Cairns BR, et al. Cell, 1996 Dec 27. PMID 8980231
    5. Rsc4 connects the chromatin remodeler RSC to RNA polymerases. Soutourina J, et al. Mol Cell Biol, 2006 Jul. PMID 16782880, Free PMC Article

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural molecule activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleosome disassembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription elongation by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RSC-type complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rsc6p
    NP_009981.1
    • Component of the RSC chromatin remodeling complex; essential for mitotic growth; RSC6 has a paralog, SNF12, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      214994..216445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178766.1 → NP_009981.1  TPA: Rsc6p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009981.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR60, P25632
      UniProtKB/TrEMBL
      B3LUB5, B5VEZ0, C7GJT4, C8Z4E4
      Conserved Domains (1) summary
      COG5531
      Location:88 → 392
      Rsc6; Chromatin remodeling complex protein RSC6, contains SWIB domain [Chromatin structure and dynamics]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25632.1

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