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    NTF2 Ran GTPase-binding protein NTF2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856727, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NTF2
    Official Full Name
    Ran GTPase-binding protein NTF2
    Primary source
    SGD:S000000811
    Locus tag
    YER009W
    See related
    AllianceGenome:SGD:S000000811; FungiDB:YER009W; VEuPathDB:YER009W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables small GTPase binding activity. Involved in protein import into nucleus. Located in nuclear envelope. Human ortholog(s) of this gene implicated in diabetic retinopathy. Orthologous to human NUTF2 (nuclear transport factor 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NTF2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (172115..172492)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene GTP-Rho binding exocyst subunit SEC3 Neighboring gene bifunctional 4-hydroxy-4-methyl-2-oxoglutarate aldolase/oxaloacetate decarboxylase Neighboring gene GPI-anchored mannoprotein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Probing a structural model of the nuclear pore complex channel through molecular dynamics. Miao L, et al. Biophys J, 2010 Apr 21. PMID 20409487, Free PMC Article
    2. The NTF2 gene encodes an essential, highly conserved protein that functions in nuclear transport in vivo. Corbett AH, et al. J Biol Chem, 1996 Aug 2. PMID 8702493
    3. Structural basis for the interaction between NTF2 and nucleoporin FxFG repeats. Bayliss R, et al. EMBO J, 2002 Jun 17. PMID 12065398, Free PMC Article
    4. Tuning Selective Transport of Biomolecules through Site-Mutated Nucleoporin-like Protein (NLP) Hydrogels. Yang YJ, et al. Biomacromolecules, 2021 Feb 8. PMID 33428378
    5. Functional analysis of the hydrophobic patch on nuclear transport factor 2 involved in interactions with the nuclear pore in vivo. Quimby BB, et al. J Biol Chem, 2001 Oct 19. PMID 11489893

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nucleocytoplasmic transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleocytoplasmic transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore central transport channel IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ran GTPase-binding protein NTF2
    NP_010925.1
    • Nuclear envelope protein; interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      172115..172492
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178900.1 → NP_010925.1  TPA: Ran GTPase-binding protein NTF2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010925.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLQ6, P33331
      UniProtKB/TrEMBL
      A6ZQV6, B3LS21, C7GKI7, C8Z709, G2WCP0, N1P5G2
      Conserved Domains (1) summary
      cd00780
      Location:4 → 123
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33331.2

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