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    NRG1 transcriptional regulator NRG1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851613, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NRG1
    Official Full Name
    transcriptional regulator NRG1
    Primary source
    SGD:S000002450
    Locus tag
    YDR043C
    See related
    AllianceGenome:SGD:S000002450; FungiDB:YDR043C; VEuPathDB:YDR043C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including negative regulation of DNA-templated transcription; negative regulation of growth of unicellular organism as a thread of attached cells; and single-species biofilm formation. Located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NRG1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (542674..543369, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene coproporphyrinogen oxidase Neighboring gene DNA-directed RNA polymerase III core subunit RPC11

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nrg1 functions as a global transcriptional repressor of glucose-repressed genes through its direct binding to the specific promoter regions. Lee SB, et al. Biochem Biophys Res Commun, 2013 Oct 4. PMID 24025681
    2. Inactivation of the UAS1 of STA1 by glucose and STA10 and identification of two loci, SNS1 and MSS1, involved in STA10-dependent repression in Saccharomyces cerevisiae. Ahn JH, et al. Mol Gen Genet, 1995 Mar 10. PMID 7700227
    3. Global analysis of eukaryotic mRNA degradation reveals Xrn1-dependent buffering of transcript levels. Sun M, et al. Mol Cell, 2013 Oct 10. PMID 24119399
    4. Nrg1 and nrg2 transcriptional repressors are differently regulated in response to carbon source. Berkey CD, et al. Eukaryot Cell, 2004 Apr. PMID 15075261, Free PMC Article
    5. Neo-functionalization in Saccharomyces cerevisiae: a novel Nrg1-Rtg3 chimeric transcriptional modulator is essential to maintain mitochondrial DNA integrity. Campero-Basaldua C, et al. R Soc Open Sci, 2023 Nov. PMID 37920568, Free PMC Article

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A specific catalytic domain isoform of casein kinase II is required for the phosphorylation of the repressor NRG1.
      Title: A specific catalytic subunit isoform of protein kinase CK2 is required for phosphorylation of the repressor Nrg1 in Saccharomyces cerevisiae.
    2. Results suggest that Nrg1/Nrg2 fine-tune the regulation of a set of stress-responsive genes.
      Title: Repressors Nrg1 and Nrg2 regulate a set of stress-responsive genes in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion involved in single-species biofilm formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular hyperosmotic salinity response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular hyperosmotic salinity response IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in negative regulation of cellular hyperosmotic salinity response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of cellular response to alkaline pH IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cellular response to alkaline pH IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in negative regulation of invasive growth in response to glucose limitation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of pseudohyphal growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in single-species surface biofilm formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transcriptional regulator NRG1
    NP_010328.3
    • Transcriptional repressor; recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response; activated in stochastic pulses of nuclear localization in response to low glucose

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      542674..543369 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180351.3 → NP_010328.3  TPA: transcriptional regulator NRG1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010328.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS31, Q03125
      UniProtKB/TrEMBL
      A6ZY10, B3LGM4, B5VFU5, C7GTA6, C8Z4W3, G2WAE8, N1P4K1
      Conserved Domains (2) summary
      COG5048
      Location:21 → 229
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:176 → 196
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03125.1

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