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    Etf1 eukaryotic translation termination factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307503, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Etf1provided by RGD
    Official Full Name
    eukaryotic translation termination factor 1provided by RGD
    Primary source
    RGD:1305712
    See related
    EnsemblRapid:ENSRNOG00000019450 AllianceGenome:RGD:1305712
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable aminoacyl-tRNA hydrolase activity; sequence-specific mRNA binding activity; and translation release factor activity, codon specific. Predicted to be involved in cytoplasmic translational termination and regulation of translational termination. Predicted to act upstream of or within protein methylation and translational termination. Predicted to be located in cytoplasm. Predicted to be part of translation release factor complex. Predicted to be active in cytosolic ribosome. Orthologous to human ETF1 (eukaryotic translation termination factor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 357.6), Muscle (RPKM 357.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Etf1 in Genome Data Viewer
    Location:
    18p12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (26776518..26804857, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (26502413..26530753, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (27698693..27725694, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene early growth response 1 Neighboring gene 5S ribosomal RNA Neighboring gene small nucleolar RNA SNORA26 Neighboring gene small nucleolar RNA SNORD63 Neighboring gene small nucleolar RNA SNORD63 Neighboring gene heat shock protein family A (Hsp70) member 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The elongation, termination, and recycling phases of translation in eukaryotes. Dever TE, et al. Cold Spring Harb Perspect Biol, 2012 Jul 1. PMID 22751155, Free PMC Article
    2. Stop codons and UGG promote efficient binding of the polypeptide release factor eRF1 to the ribosomal A site. Chavatte L, et al. J Mol Biol, 2003 Aug 22. PMID 12909007
    3. Optimal translational termination requires C4 lysyl hydroxylation of eRF1. Feng T, et al. Mol Cell, 2014 Feb 20. PMID 24486019, Free PMC Article
    4. A highly conserved eukaryotic protein family possessing properties of polypeptide chain release factor. Frolova L, et al. Nature, 1994 Dec 15. PMID 7990965
    5. Regulation of HIV-1 Gag-Pol Expression by Shiftless, an Inhibitor of Programmed -1 Ribosomal Frameshifting. Wang X, et al. Cell, 2019 Jan 24. PMID 30682371, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94734

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aminoacyl-tRNA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation release factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation release factor activity, codon specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation termination factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation termination factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cytoplasmic translational termination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of translational termination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within translational termination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translational termination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of translation release factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of translation release factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic peptide chain release factor subunit 1
    Names
    eRF1
    eukaryotic release factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008344.1 → NP_001008345.1  eukaryotic peptide chain release factor subunit 1

      See identical proteins and their annotated locations for NP_001008345.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085902
      UniProtKB/Swiss-Prot
      Q5U2Q7
      Related
      ENSRNOP00000026398.4, ENSRNOT00000026398.7
      Conserved Domains (1) summary
      COG1503
      Location:11 → 419
      eRF1; Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      26776518..26804857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096867.2 → XP_038952795.1  eukaryotic peptide chain release factor subunit 1 isoform X1

      UniProtKB/TrEMBL
      A6J2W8
      Conserved Domains (1) summary
      COG1503
      Location:1 → 386
      eRF1; Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U2Q7.3 GenPept UniProtKB/Swiss-Prot:Q5U2Q7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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    Tools
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