Cep78 centrosomal protein 78 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cep78provided by RGD
Official Full Name: centrosomal protein 78provided by RGD
Primary source: RGD:620464
See related: EnsemblRapid:ENSRNOG00000014041 AllianceGenome:RGD:620464
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ip63
Summary: Predicted to be involved in several processes, including flagellated sperm motility; negative regulation of protein ubiquitination; and protein localization to centrosome. Predicted to be active in centriole; centrosome; and ciliary basal body. Orthologous to human CEP78 (centrosomal protein 78). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 44.6), Thymus (RPKM 41.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (222674193..222702124, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (213246183..213275275, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (233185815..233214876, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Got211 (e-PCR)
- UniSTS:112180

BE107381 (e-PCR)
- UniSTS:261549

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in cilium organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium organization	ISO Inferred from Sequence Orthology more info
involved_in flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein localization to centrosome	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cilium	IEA Inferred from Electronic Annotation more info
involved_in protein localization to cilium	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in centriole	ISO Inferred from Sequence Orthology more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: centrosomal protein of 78 kDa

Names: centrosomal protein 78kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021741.2 → NP_068509.2 centrosomal protein of 78 kDa

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001, X99330

UniProtKB/TrEMBL

A6I0H6, F1LP29

Related

ENSRNOP00000018951.5, ENSRNOT00000018951.8

Conserved Domains (2) summary

cd00116
Location:113 → 299

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cl09820
Location:413 → 485

PhaP_Bmeg; Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

222674193..222702124 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006231136.5 → XP_006231198.1 centrosomal protein of 78 kDa isoform X1

See identical proteins and their annotated locations for XP_006231198.1

UniProtKB/TrEMBL

A6I0H6, A6I0H7

Conserved Domains (2) summary

cd00116
Location:113 → 299

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cl09820
Location:413 → 485

PhaP_Bmeg; Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg)
XM_063272456.1 → XP_063128526.1 centrosomal protein of 78 kDa isoform X6
XM_039088989.2 → XP_038944917.1 centrosomal protein of 78 kDa isoform X2

UniProtKB/TrEMBL

A6I0H6

Conserved Domains (1) summary

cl39015
Location:23 → 217

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_039088994.2 → XP_038944922.1 centrosomal protein of 78 kDa isoform X5

Conserved Domains (1) summary

cl39015
Location:113 → 299

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_039088993.2 → XP_038944921.1 centrosomal protein of 78 kDa isoform X4

Conserved Domains (1) summary

cl39015
Location:113 → 299

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_039088991.2 → XP_038944919.1 centrosomal protein of 78 kDa isoform X3

UniProtKB/TrEMBL

A6I0H6

Conserved Domains (1) summary

cl39015
Location:23 → 217

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...