Tjp2 tight junction protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Tjp2provided by RGD
Full Name: tight junction protein 2provided by RGD
Primary source: RGD:619807
See related: EnsemblRapid:ENSRNOG00000015030 AllianceGenome:RGD:619807
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ZO-2
Summary: Enables transmembrane transporter binding activity. Predicted to be involved in several processes, including establishment of endothelial intestinal barrier; positive regulation of blood-brain barrier permeability; and protein localization to cell-cell junction. Predicted to act upstream of or within negative regulation of osteoclast development and negative regulation of tumor necrosis factor-mediated signaling pathway. Located in bicellular tight junction. Biomarker of hypertension. Human ortholog(s) of this gene implicated in disease of metabolism and progressive familial intrahepatic cholestasis 4. Orthologous to human TJP2 (tight junction protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 119.7), Kidney (RPKM 54.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q51

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (231136218..231264750, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (221709745..221838291, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (241945816..242084044, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZO-2 favors Hippo signaling, and its re-expression in the steatotic liver by AMPK restores junctional sealing.
Title: ZO-2 favors Hippo signaling, and its re-expression in the steatotic liver by AMPK restores junctional sealing.
crucial roles in basal salivary epithelial barrier function and TRPV1-modulated paracellular transport
Title: ZO-1 and -2 Are Required for TRPV1-Modulated Paracellular Permeability.
ZO-2 suppression decreased cyclin D1 abundance and the depletion of which restored cell cycle progression.
Title: Different effects of ZO-1, ZO-2 and ZO-3 silencing on kidney collecting duct principal cell proliferation and adhesion.
Levels of tight junction protein ZO2 are decreased in blood brain barrier cells post-translationally following neurotoxicant administration.
Title: Assessments of tight junction proteins occludin, claudin 5 and scaffold proteins ZO1 and ZO2 in endothelial cells of the rat blood-brain barrier: cellular responses to neurotoxicants malathion and lead acetate.
Fg binding to endothelial cells (ECs) alters expression of actin-associated endothelial tight junction proteins.
Title: Fibrinogen induces alterations of endothelial cell tight junction proteins.
The highly increased expression and changed distribution of ZO-2 suggests that ZO-1 is partly substituted by ZO-2, an alteration possibly causing impaired barrier function.
Title: Bile duct ligation in the rat causes upregulation of ZO-2 and decreased colocalization of claudins with ZO-1 and occludin.
Connexin 43 interacts with zona occludens-1 and -2 proteins in a cell cycle stage-specific manner
Title: Connexin 43 interacts with zona occludens-1 and -2 proteins in a cell cycle stage-specific manner.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH132796 (e-PCR)
- UniSTS:216079

RH132524 (e-PCR)
- UniSTS:215807

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell junction organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of endothelial intestinal barrier	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of endothelial intestinal barrier	ISO Inferred from Sequence Orthology more info
involved_in homotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in intestinal absorption	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of osteoclast development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood-brain barrier permeability	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of blood-brain barrier permeability	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of membrane permeability	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in bicellular tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell-cell contact zone	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in tight junction	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tight junction protein ZO-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001414504.1 → NP_001401433.1 tight junction protein ZO-2 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6ALD4, A0A8J8Y4W9, A6I0Q1

Related

ENSRNOP00000062549.3, ENSRNOT00000065921.5
NM_053773.3 → NP_446225.1 tight junction protein ZO-2 isoform 2

See identical proteins and their annotated locations for NP_446225.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6ALD4, E9PTS1, Q3ZB99

Conserved Domains (5) summary

cd12027
Location:584 → 646

SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2

smart00072
Location:680 → 859

GuKc; Guanylate kinase homologues

smart00228
Location:288 → 365

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:9 → 94

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam08648
Location:185 → 285

DUF1777; Protein of unknown function (DUF1777)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

231136218..231264750 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006231176.4 → XP_006231238.2 tight junction protein ZO-2 isoform X6

UniProtKB/TrEMBL

A0A8I6ALD4, A0A8I6AP88

Related

ENSRNOP00000095687.1, ENSRNOT00000094702.2

Conserved Domains (5) summary

cd12027
Location:584 → 646

SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2

smart00072
Location:680 → 859

GuKc; Guanylate kinase homologues

smart00228
Location:288 → 365

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:9 → 94

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam17069
Location:125 → 277

RSRP; Arginine/Serine-Rich protein 1
XM_039109085.2 → XP_038965013.1 tight junction protein ZO-2 isoform X5

UniProtKB/TrEMBL

A0A8I6ALD4

Conserved Domains (5) summary

cd12027
Location:607 → 669

SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2

smart00072
Location:703 → 882

GuKc; Guanylate kinase homologues

smart00228
Location:311 → 388

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:32 → 117

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam17069
Location:148 → 300

RSRP; Arginine/Serine-Rich protein 1
XM_006231178.5 → XP_006231240.1 tight junction protein ZO-2 isoform X2

See identical proteins and their annotated locations for XP_006231240.1

UniProtKB/TrEMBL

A0A8I6ALD4, A0A8I6GLX8, A6I0Q0

Related

ENSRNOP00000096118.1, ENSRNOT00000103927.2

Conserved Domains (5) summary

cd12027
Location:607 → 669

SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2

smart00072
Location:703 → 882

GuKc; Guanylate kinase homologues

smart00228
Location:311 → 388

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:32 → 117

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam08648
Location:208 → 308

DUF1777; Protein of unknown function (DUF1777)
XM_039109067.2 → XP_038964995.1 tight junction protein ZO-2 isoform X3

UniProtKB/TrEMBL

A0A8I6ALD4

Related

ENSRNOP00000107921.1, ENSRNOT00000167191.1

Conserved Domains (5) summary

cd12027
Location:601 → 663

SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2

smart00072
Location:697 → 876

GuKc; Guanylate kinase homologues

smart00228
Location:305 → 382

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:26 → 111

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam17069
Location:142 → 294

RSRP; Arginine/Serine-Rich protein 1
XM_006231182.5 → XP_006231244.1 tight junction protein ZO-2 isoform X4

UniProtKB/TrEMBL

A0A8I6ALD4

Conserved Domains (6) summary

cd12027
Location:611 → 673

SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2

smart00072
Location:707 → 886

GuKc; Guanylate kinase homologues

smart00228
Location:315 → 392

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:36 → 121

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam08648
Location:212 → 312

DUF1777; Protein of unknown function (DUF1777)

pfam12871
Location:214 → 292

PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
XM_006231177.5 → XP_006231239.1 tight junction protein ZO-2 isoform X1

UniProtKB/TrEMBL

A0A8I6ALD4

Related

ENSRNOP00000101092.1, ENSRNOT00000148916.1

Conserved Domains (5) summary

cd12027
Location:611 → 673

SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2

smart00072
Location:707 → 886

GuKc; Guanylate kinase homologues

smart00228
Location:315 → 392

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:36 → 121

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam08648
Location:212 → 312

DUF1777; Protein of unknown function (DUF1777)