Igha immunoglobulin heavy constant alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ighaprovided by MGI
Official Full Name: immunoglobulin heavy constant alphaprovided by MGI
Primary source: MGI:MGI:96444
See related: Ensembl:ENSMUSG00000095079 IMGT/GENE-DB:IGHA; AllianceGenome:MGI:96444
Gene type: other
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IgA; Igh-2
Summary: Enables antigen binding activity. Acts upstream of or within humoral immune response mediated by circulating immunoglobulin and mucosal immune response. Part of immunoglobulin complex, circulating. Is expressed in large intestine and small intestine. Orthologous to human IGHA1 (immunoglobulin heavy constant alpha 1) and IGHA2 (immunoglobulin heavy constant alpha 2 (A2m marker)). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: 12 F1; 12 62.09 cM

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (113219824..113223856, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (113256204..113260236, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bacteria-Induced Group 2 Innate Lymphoid Cells in the Stomach Provide Immune Protection through Induction of IgA.
Title: Bacteria-Induced Group 2 Innate Lymphoid Cells in the Stomach Provide Immune Protection through Induction of IgA.
In transgenic mice, IgAN pathogenesis involves impaired clearance of abnormal IgA via CD89, primarily by the Kupffer cells. Conditional IgAN progression in CD89 transgenic mice thus reveals important aspects of IgAN pathogenesis.
Title: Critical Role of Kupffer Cell CD89 Expression in Experimental IgA Nephropathy.
Increased production of IL-5 from Peyer's patch cells and the restored Th1-type immune response might cause the production of abnormal IgA and might induce the glomerular deposition of IgA in IGA nephropathy.
Title: Release from Th1-type immune tolerance in spleen and enhanced production of IL-5 in Peyer's patch by cholera toxin B induce the glomerular deposition of IgA.
pIgR/SIgA deficiency in the airways leads to persistent activation of innate immune responses to resident lung microbiota, driving progressive small airway remodelling and emphysema.
Title: Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency.
The differential and synergistic effect of retinoic acid and TGF-beta on switching of different B cell subpopulations to IgA, is reported.
Title: An intrinsic propensity of murine peritoneal B1b cells to switch to IgA in presence of TGF-β and retinoic acid.
Our data suggest a critical role of O-linked glycans attached to the hinge region in the development of IgA nephropathy-like disease induced by 6-19 IgA rheumatoid factor in mice.
Title: O-linked glycosylation determines the nephritogenic potential of IgA rheumatoid factor.
Data indicate the importance of the mucosal IgA response in defense against HIV/AIDS.
Title: Inhibitory effect of HIV-specific neutralizing IgA on mucosal transmission of HIV in humanized mice.
Glycosylation of the CH2/CH3 interface inhibits interaction with the pathogen IgA binding protein SSL7, while maintaining binding of pIgR, essential to the biosynthesis and transport of SIgA.
Title: Interaction of human, rat, and mouse immunoglobulin A (IgA) with Staphylococcal superantigen-like 7 (SSL7) decoy protein and leukocyte IgA receptor.
Caloric restriction reduces IgA levels and modifies cytokine mRNA expression in mouse small intestine
Title: Caloric restriction reduces IgA levels and modifies cytokine mRNA expression in mouse small intestine.
Aberrant glycosylation of immunoglobulin A causes IGA nephropathy. (review)
Title: [Aberrant glycosylation of immunoglobulin A and renal disease].

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Targeted (3) 1 citation

General gene information

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Markers

AI893585 (e-PCR)
- UniSTS:180483

Igh-Ia (e-PCR), detects polymorphism
- UniSTS:461921

PMC305257P1 (e-PCR)
- UniSTS:272539

RH137281 (e-PCR)
- UniSTS:219369

AI661180 (e-PCR)
- UniSTS:180478

Other Names

immunoglobulin heavy chain 2 (serum IgA)

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables antigen binding	IBA Inferred from Biological aspect of Ancestor more info
enables antigen binding	IDA Inferred from Direct Assay more info	PubMed
enables immunoglobulin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to immunoglobulin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	IBA Inferred from Biological aspect of Ancestor more info
involved_in complement activation, classical pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within humoral immune response mediated by circulating immunoglobulin	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within immunoglobulin mediated immune response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within mucosal immune response	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of immunoglobulin complex, circulating	IBA Inferred from Biological aspect of Ancestor more info
part_of immunoglobulin complex, circulating	IDA Inferred from Direct Assay more info	PubMed
part_of monomeric IgA immunoglobulin complex	ISO Inferred from Sequence Orthology more info
part_of secretory IgA immunoglobulin complex	ISO Inferred from Sequence Orthology more info
part_of secretory dimeric IgA immunoglobulin complex	ISO Inferred from Sequence Orthology more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_005838.1

Range

8608..12640 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

113219824..113223856 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001024700.1: Suppressed sequence

Description

NM_001024700.1: This RefSeq was permanently suppressed because immunoglobulin and T-cell receptor loci are out of scope for RefSeq transcripts.