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    Zfyve28 zinc finger, FYVE domain containing 28 [ Mus musculus (house mouse) ]

    Gene ID: 231125, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Zfyve28provided by MGI
    Official Full Name
    zinc finger, FYVE domain containing 28provided by MGI
    Primary source
    MGI:MGI:2684992
    See related
    Ensembl:ENSMUSG00000037224 AllianceGenome:MGI:2684992
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm146; mKIAA1643; 9630058O20Rik
    Summary
    Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in negative regulation of epidermal growth factor-activated receptor activity. Predicted to be located in cytosol. Predicted to be active in early endosome membrane. Orthologous to human ZFYVE28 (zinc finger FYVE-type containing 28). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in cerebellum adult (RPKM 4.9), cortex adult (RPKM 3.0) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfyve28 in Genome Data Viewer
    Location:
    5 B2; 5 17.85 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (34352237..34445796, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (34194893..34288368, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene DNA polymerase N Neighboring gene STARR-positive B cell enhancer ABC_E1299 Neighboring gene STARR-seq mESC enhancer starr_12836 Neighboring gene predicted gene, 25918 Neighboring gene HAUS augmin-like complex, subunit 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:34530746-34530855 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:34537815-34537924 Neighboring gene Max dimerization protein 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:34575558-34575759 Neighboring gene cilia and flagella associated protein 99 Neighboring gene RIKEN cDNA A830049F12 gene Neighboring gene predicted gene 5553 Neighboring gene STARR-positive B cell enhancer ABC_E668 Neighboring gene ring finger protein 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ZFYVE28 mediates insulin resistance by promoting phosphorylated insulin receptor degradation via increasing late endosomes production. Yu L, et al. Nat Commun, 2023 Oct 26. PMID 37884540, Free PMC Article
    2. FYVE domain-containing protein ZFYVE28 regulates EGFR-signaling in podocytes but is not critical for the function of filtration barrier in mice. Zambrano S, et al. Sci Rep, 2018 Mar 16. PMID 29549365, Free PMC Article
    3. Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation. Alvarez-Dominguez JR, et al. Blood, 2014 Jan 23. PMID 24200680, Free PMC Article
    4. Widespread and dynamic translational control of red blood cell development. Alvarez-Dominguez JR, et al. Blood, 2017 Feb 2. PMID 27899360, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • AC104889.1

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of epidermal growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of epidermal growth factor-activated receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of epidermal growth factor-activated receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in early endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    lateral signaling target protein 2 homolog
    Names
    zinc finger FYVE domain-containing protein 28

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015039.1 → NP_001015039.1  lateral signaling target protein 2 homolog

      Status: PROVISIONAL

      Source sequence(s)
      AK129414
      Consensus CDS
      CCDS39068.1
      UniProtKB/Swiss-Prot
      B2RSX8, Q6ZPK7
      Related
      ENSMUSP00000092464.4, ENSMUST00000094868.10
      Conserved Domains (1) summary
      cd15731
      Location:828 → 892
      FYVE_LST2; FYVE domain found in lateral signaling target protein 2 homolog (Lst2) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      34352237..34445796 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503886.2 → XP_006503949.1  lateral signaling target protein 2 homolog isoform X2

      Conserved Domains (1) summary
      cd15731
      Location:781 → 845
      FYVE_LST2; FYVE domain found in lateral signaling target protein 2 homolog (Lst2) and similar proteins

    2. XM_036165019.1 → XP_036020912.1  lateral signaling target protein 2 homolog isoform X1

      Conserved Domains (1) summary
      cd15731
      Location:724 → 788
      FYVE_LST2; FYVE domain found in lateral signaling target protein 2 homolog (Lst2) and similar proteins

    3. XM_011240724.1 → XP_011239026.1  lateral signaling target protein 2 homolog isoform X4

      Conserved Domains (1) summary
      cd15731
      Location:323 → 387
      FYVE_LST2; FYVE domain found in lateral signaling target protein 2 homolog (Lst2) and similar proteins

    4. XM_006503887.1 → XP_006503950.1  lateral signaling target protein 2 homolog isoform X3

      Conserved Domains (1) summary
      cd15731
      Location:614 → 678
      FYVE_LST2; FYVE domain found in lateral signaling target protein 2 homolog (Lst2) and similar proteins

    5. XM_017320831.3 → XP_017176320.1  lateral signaling target protein 2 homolog isoform X5

      Conserved Domains (1) summary
      cd15731
      Location:494 → 558
      FYVE_LST2; FYVE domain found in lateral signaling target protein 2 homolog (Lst2) and similar proteins

    6. XM_011240725.2 → XP_011239027.1  lateral signaling target protein 2 homolog isoform X6

    7. XM_011240726.4 → XP_011239028.2  lateral signaling target protein 2 homolog isoform X8

    8. XM_011240727.4 → XP_011239029.2  lateral signaling target protein 2 homolog isoform X9

    9. XM_011240728.2 → XP_011239030.1  lateral signaling target protein 2 homolog isoform X7

    RNA

    1. XR_003955626.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZPK7.2 GenPept UniProtKB/Swiss-Prot:Q6ZPK7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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