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    Mblac1 metallo-beta-lactamase domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 330216, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mblac1provided by MGI
    Official Full Name
    metallo-beta-lactamase domain containing 1provided by MGI
    Primary source
    MGI:MGI:2679717
    See related
    Ensembl:ENSMUSG00000049285 AllianceGenome:MGI:2679717
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable RNA endonuclease activity and metal ion binding activity. Predicted to be involved in histone mRNA metabolic process; mRNA 3'-end processing; and positive regulation of G1/S transition of mitotic cell cycle. Predicted to be located in cytoplasm and nucleus. Orthologous to human MBLAC1 (metallo-beta-lactamase domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human all
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    Genomic context

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    See Mblac1 in Genome Data Viewer
    Location:
    5 G2; 5 76.98 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (138192576..138193883)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (138194314..138195621)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene adaptor-related protein complex AP-4, mu 1 Neighboring gene STARR-seq mESC enhancer starr_14665 Neighboring gene TATA-box binding protein associated factor 6 Neighboring gene canopy FGF signaling regulator 4 Neighboring gene predicted gene 454 Neighboring gene neurexophilin and PC-esterase domain family, member 5 Neighboring gene predicted gene, 22956

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Optical Imaging Reveals Liver Metabolic Perturbations in Mblac1 Knockout Mice. Ceyhan B, et al. Annu Int Conf IEEE Eng Med Biol Soc, 2023 Jul. PMID 38083729
    2. Global untargeted serum metabolomic analyses nominate metabolic pathways responsive to loss of expression of the orphan metallo β-lactamase, MBLAC1. Gibson CL , et al. Mol Omics, 2018 Jun 12. PMID 29868674, Free PMC Article
    3. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Optical Imaging Reveals Liver Metabolic Perturbations in Mblac1 Knockout Mice.
      Title: Optical Imaging Reveals Liver Metabolic Perturbations in Mblac1 Knockout Mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC49416

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA endonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in histone mRNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in histone mRNA metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mRNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of G1/S transition of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    metallo-beta-lactamase domain-containing protein 1
    Names
    endoribonuclease MBLAC1
    NP_808546.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177878.3 → NP_808546.1  metallo-beta-lactamase domain-containing protein 1

      See identical proteins and their annotated locations for NP_808546.1

      Status: VALIDATED

      Source sequence(s)
      AI314927, AK049381
      Consensus CDS
      CCDS19796.1
      UniProtKB/Swiss-Prot
      Q8BWY4, Q8CHU7
      Related
      ENSMUSP00000052869.5, ENSMUST00000057773.5
      Conserved Domains (2) summary
      COG0491
      Location:81 → 244
      GloB; Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II [General function prediction only]
      cd07711
      Location:24 → 240
      MBLAC1-like_MBL-fold; uncharacterized human metallo-beta-lactamase domain-containing protein 1 and related proteins; MBL-fold metallo hydrolase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      138192576..138193883
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BWY4.1 GenPept UniProtKB/Swiss-Prot:Q8BWY4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools