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    GID7 glucose-induced degradation complex subunit GID7 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850318, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GID7
    Official Full Name
    glucose-induced degradation complex subunit GID7
    Primary source
    SGD:S000000544
    Locus tag
    YCL039W
    See related
    AllianceGenome:SGD:S000000544; FungiDB:YCL039W; VEuPathDB:YCL039W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MOH2
    Summary
    Involved in negative regulation of gluconeogenesis and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in peroxisome. Part of GID complex. Orthologous to human WDR26 (WD repeat domain 26). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GID7 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (52645..54882)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene protein disulfide isomerase PDI1 Neighboring gene uncharacterized protein Neighboring gene glucokinase Neighboring gene Atg22p Neighboring gene Sro9p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of genes affecting glucose catabolism in nitrogen-limited fermentation. Gardner JM, et al. FEMS Yeast Res, 2005 Jun. PMID 15925307
    2. Exploring the topology of the Gid complex, the E3 ubiquitin ligase involved in catabolite-induced degradation of gluconeogenic enzymes. Menssen R, et al. J Biol Chem, 2012 Jul 20. PMID 22645139, Free PMC Article
    3. Cryo-EM structures of Gid12-bound GID E3 reveal steric blockade as a mechanism inhibiting substrate ubiquitylation. Qiao S, et al. Nat Commun, 2022 Jun 1. PMID 35650207, Free PMC Article
    4. The yeast GID complex, a novel ubiquitin ligase (E3) involved in the regulation of carbohydrate metabolism. Santt O, et al. Mol Biol Cell, 2008 Aug. PMID 18508925, Free PMC Article
    5. Effects of mutations of GID protein-coding genes on malate production and enzyme expression profiles in Saccharomyces cerevisiae. Negoro H, et al. Appl Microbiol Biotechnol, 2020 Jun. PMID 32248437

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of GID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GID complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glucose-induced degradation complex subunit GID7
    NP_009891.1
    • Subunit of GID Complex that binds directly to central component Vid30p; GID complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; Gid7p contains six WD40 repeats; localizes to peroxisomes in oleate-growing cells; computational analysis suggests that Gid7p and Moh1p have similar functions

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      52645..54882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178684.1 → NP_009891.1  TPA: glucose-induced degradation complex subunit GID7 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009891.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQX6, P25569
      UniProtKB/TrEMBL
      A6ZTF1, B5VES1, N1PAP0
      Conserved Domains (2) summary
      sd00039
      Location:327 → 369
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:318 → 741
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25569.2

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