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    TAF13 Taf13p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854875, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TAF13
    Official Full Name
    Taf13p
    Primary source
    SGD:S000004564
    Locus tag
    YML098W
    See related
    AllianceGenome:SGD:S000004564; FungiDB:YML098W; VEuPathDB:YML098W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    FUN81; TAF19
    Summary
    Predicted to enable protein heterodimerization activity. Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Involved in RNA polymerase II preinitiation complex assembly. Located in nucleus. Part of transcription factor TFIID complex. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 60. Orthologous to human TAF13 (TATA-box binding protein associated factor 13). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TAF13 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (77267..77770)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene trehalose 6-phosphate synthase/phosphatase complex subunit Neighboring gene Arg81p Neighboring gene guanine nucleotide exchange factor VPS9 Neighboring gene putative asparagine synthase Neighboring gene DNA repair protein RAD10

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of two new genes essential for vegetative growth in Saccharomyces cerevisiae: nucleotide sequence determination and chromosome mapping. Dubois E, et al. Gene, 1987. PMID 3311883
    2. Involvement of the SAGA and TFIID coactivator complexes in transcriptional dysregulation caused by the separation of core and tail Mediator modules. Saleh MM, et al. G3 (Bethesda), 2022 Dec 1. PMID 36331351, Free PMC Article
    3. TFIID-specific yeast TAF40 is essential for the majority of RNA polymerase II-mediated transcription in vivo. Komarnitsky PB, et al. Genes Dev, 1999 Oct 1. PMID 10521393, Free PMC Article
    4. The TATA-binding protein-associated factor yTafII19p functionally interacts with components of the global transcriptional regulator Ccr4-Not complex and physically interacts with the Not5 subunit. Lemaire M, et al. J Biol Chem, 2000 Sep 1. PMID 10864925
    5. Yeast homologues of higher eukaryotic TFIID subunits. Moqtaderi Z, et al. Proc Natl Acad Sci U S A, 1996 Dec 10. PMID 8962109, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to RNA polymerase II general transcription initiation factor activity IC
    Inferred by Curator
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA polymerase II preinitiation complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIID complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Taf13p
    NP_013611.1
    • TFIID subunit (19 kDa); involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      77267..77770
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182458.1 → NP_013611.1  TPA: Taf13p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013611.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0I7, P11747
      UniProtKB/TrEMBL
      C7GV80, G2WJV9
      Conserved Domains (1) summary
      COG5248
      Location:1 → 133
      TAF19; Transcription initiation factor TFIID, subunit TAF13 [Transcription]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P11747.2

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