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    Naalad2 N-acetylated alpha-linked acidic dipeptidase 2 [ Mus musculus (house mouse) ]

    Gene ID: 72560, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Naalad2provided by MGI
    Official Full Name
    N-acetylated alpha-linked acidic dipeptidase 2provided by MGI
    Primary source
    MGI:MGI:1919810
    See related
    Ensembl:ENSMUSG00000043943 AllianceGenome:MGI:1919810
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GCP3; Folh1b; GCPIII; D9Ertd285e; NAADALASE2; NAALADASE2; 2700022G20Rik
    Summary
    Enables N-formylglutamate deformylase activity and carboxypeptidase activity. Involved in carboxylic acid catabolic process. Acts upstream of or within proteolysis. Located in membrane. Orthologous to human NAALAD2 (N-acetylated alpha-linked acidic dipeptidase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 3.8), testis adult (RPKM 1.8) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Naalad2 in Genome Data Viewer
    Location:
    9 A2; 9 7.02 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (18233247..18308834, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (18321951..18397538, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23416 Neighboring gene predicted gene, 51667 Neighboring gene predicted gene 7692 Neighboring gene cysteine and histidine rich domain containing 1 Neighboring gene amyloid beta (A4) precursor protein-binding, family B, member 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_23417 Neighboring gene upstream binding transcription factor, RNA polymerase I-like 1 pseudogene Neighboring gene upstream binding transcription factor, RNA polymerase I-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Parallel Metabolomics and Lipidomics of a PSMA/GCPII Deficient Mouse Model Reveal Alteration of NAAG Levels and Brain Lipid Composition. Sedlák F, et al. ACS Chem Neurosci, 2024 Apr 3. PMID 38377674, Free PMC Article
    2. Deletion of glutamate carboxypeptidase II (GCPII), but not GCPIII, provided long-term benefits in mice with traumatic brain injury. Ji T, et al. CNS Neurosci Ther, 2023 Dec. PMID 37349952, Free PMC Article
    3. The cloning and characterization of a second brain enzyme with NAAG peptidase activity. Bzdega T, et al. J Neurochem, 2004 May. PMID 15086519
    4. Molecular identification of β-citrylglutamate hydrolase as glutamate carboxypeptidase 3. Collard F, et al. J Biol Chem, 2011 Nov 4. PMID 21908619, Free PMC Article
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deletion of glutamate carboxypeptidase II (GCPII), but not GCPIII, provided long-term benefits in mice with traumatic brain injury.
      Title: Deletion of glutamate carboxypeptidase II (GCPII), but not GCPIII, provided long-term benefits in mice with traumatic brain injury.
    2. analysis of GCP2 and GCP3; beta-citrylglutamate hydrolase is glutamate carboxypeptidase 3
      Title: Molecular identification of β-citrylglutamate hydrolase as glutamate carboxypeptidase 3.
    3. cloning and characterization of a mouse enzyme that is homologous to an enzyme identified in a human lung carcinoma.
      Title: The cloning and characterization of a second brain enzyme with NAAG peptidase activity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Targeted (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124348, MGC124349

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-formylglutamate deformylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carboxypeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dipeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallocarboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carboxylic acid catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    N-acetylated-alpha-linked acidic dipeptidase 2
    Names
    N-acetylaspartylglutamate peptidase II
    N-acetylated-alpha-linked acidic dipeptidase II
    NAAG-peptidase II
    NAALADase II
    glutamate carboxypeptidase III
    NP_001344328.1
    NP_001344329.1
    NP_082555.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357399.2 → NP_001344328.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC154699, AC162941
      Consensus CDS
      CCDS90504.1
      UniProtKB/TrEMBL
      G3UWC2, Q3TTB7
      Related
      ENSMUSP00000130752.2, ENSMUST00000172171.8
      Conserved Domains (4) summary
      cd08022
      Location:376 → 623
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      cd02121
      Location:148 → 374
      PA_GCPII_like; PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to ...
      pfam04253
      Location:660 → 771
      TFR_dimer; Transferrin receptor-like dimerisation domain
      cl14876
      Location:86 → 142
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    2. NM_001357400.2 → NP_001344329.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC154699, AC162941
      Consensus CDS
      CCDS90504.1
      UniProtKB/TrEMBL
      G3UWC2, Q3TTB7
      Related
      ENSMUSP00000001826.9, ENSMUST00000001826.15
      Conserved Domains (4) summary
      cd08022
      Location:376 → 623
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      cd02121
      Location:148 → 374
      PA_GCPII_like; PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to ...
      pfam04253
      Location:660 → 771
      TFR_dimer; Transferrin receptor-like dimerisation domain
      cl14876
      Location:86 → 142
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    3. NM_028279.5 → NP_082555.2  N-acetylated-alpha-linked acidic dipeptidase 2 isoform b

      See identical proteins and their annotated locations for NP_082555.2

      Status: VALIDATED

      Source sequence(s)
      AC154699, AC162941
      Consensus CDS
      CCDS52728.1
      UniProtKB/Swiss-Prot
      Q80YF8, Q9CZR2
      UniProtKB/TrEMBL
      Q32MS9, Q3UZV6
      Related
      ENSMUSP00000128674.2, ENSMUST00000166825.8
      Conserved Domains (4) summary
      cd08022
      Location:338 → 585
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      cd02121
      Location:110 → 336
      PA_GCPII_like; PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to ...
      pfam04253
      Location:622 → 736
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl14876
      Location:48 → 104
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      18233247..18308834 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZR2.2 GenPept UniProtKB/Swiss-Prot:Q9CZR2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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