GET4 Get4p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: GET4
Official Full Name: Get4p
Primary source: SGD:S000005690
Locus tag: YOR164C
See related: AllianceGenome:SGD:S000005690; FungiDB:YOR164C; VEuPathDB:YOR164C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ENV8
Summary: Involved in post-translational protein targeting to endoplasmic reticulum membrane. Located in cytoplasm. Part of TRC complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to human GET4 (guided entry of tail-anchored proteins factor 4). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Ribosome-bound Get4/5 facilitates the capture of tail-anchored proteins by Sgt2 in yeast.
Title: Ribosome-bound Get4/5 facilitates the capture of tail-anchored proteins by Sgt2 in yeast.
Get5 carboxyl-terminal domain is a novel dimerization motif that tethers an extended Get4/Get5 complex.
Title: Get5 carboxyl-terminal domain is a novel dimerization motif that tethers an extended Get4/Get5 complex.
Interaction surface and topology of Get3-Get4-Get5 protein complex, involved in targeting tail-anchored proteins to endoplasmic reticulum
Title: Interaction surface and topology of Get3-Get4-Get5 protein complex, involved in targeting tail-anchored proteins to endoplasmic reticulum.
a structural model of the Sgt2-Get4/Get5-HSC complex.
Title: A structural model of the Sgt2 protein and its interactions with chaperones and the Get4/Get5 complex.
Data provide further evidence for a model in which Get4/5 operates upstream of Get3 and mediates the specific delivery of a TA substrate.
Title: Structural characterization of the Get4/Get5 complex and its interaction with Get3.
the Get4-Get5 complex interacts with Sgt2, Get3, and Ydj1
Title: Crystal structure of Get4-Get5 complex and its interactions with Sgt2, Get3, and Ydj1.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in post-translational protein targeting to endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in protein insertion into ER membrane	HGI more info	PubMed
involved_in protein insertion into ER membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein insertion into ER membrane	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of TRC complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TRC complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

NP_014807.3

Protein involved in inserting tail-anchored proteins into ER membranes; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20