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    BUD31 U2 snRNP complex subunit BUD31 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850427, updated on 9-Dec-2024

    Summary

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    Official Symbol
    BUD31
    Official Full Name
    U2 snRNP complex subunit BUD31
    Primary source
    SGD:S000000659
    Locus tag
    YCR063W
    See related
    AllianceGenome:SGD:S000000659; FungiDB:YCR063W; VEuPathDB:YCR063W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CWC14
    Summary
    Involved in mRNA splicing, via spliceosome. Located in nucleus. Part of U2 snRNP. Orthologous to human BUD31 (BUD31 homolog). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See BUD31 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (228318..228791)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Tvs1p Neighboring gene tRNA-Ser Neighboring gene Hcm1p Neighboring gene E3 ubiquitin-protein ligase RAD18

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Bayesian framework for combining heterogeneous data sources for gene function prediction (in Saccharomyces cerevisiae). Troyanskaya OG, et al. Proc Natl Acad Sci U S A, 2003 Jul 8. PMID 12826619, Free PMC Article
    2. ¹¹³Cd NMR experiments reveal an unusual metal cluster in the solution structure of the yeast splicing protein Bud31p. van Roon AM, et al. Angew Chem Int Ed Engl, 2015 Apr 13. PMID 25703931, Free PMC Article
    3. (113)Cd NMR Experiments Reveal an Unusual Metal Cluster in the Solution Structure of the Yeast Splicing Protein Bud31p. van Roon AM, et al. Angew Chem Weinheim Bergstr Ger, 2015 Apr 13. PMID 27478262, Free PMC Article
    4. Context dependent splicing functions of Bud31/Ycr063w define its role in budding and cell cycle progression. Saha D, et al. Biochem Biophys Res Commun, 2012 Aug 3. PMID 22789856
    5. Saccharomyces cerevisiae NineTeen complex (NTC)-associated factor Bud31/Ycr063w assembles on precatalytic spliceosomes and improves first and second step pre-mRNA splicing efficiency. Saha D, et al. J Biol Chem, 2012 Feb 17. PMID 22215661, Free PMC Article

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. genetic interactions between BUD31 and PRP17 were examined.
      Title: Context dependent splicing functions of Bud31/Ycr063w define its role in budding and cell cycle progression.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular bud site selection HMP PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U2 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    U2 snRNP complex subunit BUD31
    NP_009990.1
    • Component of the SF3b subcomplex of the U2 snRNP; increases efficiency of first and second step pre-mRNA splicing; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      228318..228791
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178774.1 → NP_009990.1  TPA: U2 snRNP complex subunit BUD31 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009990.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR67, P25337
      UniProtKB/TrEMBL
      A6ZTN8, B3LUC2, C7GUY1, C8Z4F2, G2WA74, N1P7W4
      Conserved Domains (1) summary
      pfam01125
      Location:1 → 155
      G10; G10 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25337.1

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