DDP1 polyphosphatase DDP1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: DDP1
Official Full Name: polyphosphatase DDP1
Primary source: SGD:S000005689
Locus tag: YOR163W
See related: AllianceGenome:SGD:S000005689; FungiDB:YOR163W; VEuPathDB:YOR163W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables phosphodiesterase decapping endonuclease activity and pyrophosphatase activity. Involved in diadenosine polyphosphate catabolic process and polyphosphate catabolic process. Located in cytoplasm and nucleus. Orthologous to several human genes including NUDT10 (nudix hydrolase 10); NUDT3 (nudix hydrolase 3); and NUDT4 (nudix hydrolase 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See DDP1 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (642741..643307)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ddp1 Cooperates with Ppx1 to Counter a Stress Response Initiated by Nonvacuolar Polyphosphate.
Title: Ddp1 Cooperates with Ppx1 to Counter a Stress Response Initiated by Nonvacuolar Polyphosphate.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ha2747 (e-PCR)
- UniSTS:515592

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables bis(5'-adenosyl)-hexaphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables bis(5'-adenosyl)-hexaphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables bis(5'-adenosyl)-hexaphosphatase activity	IEA Inferred from Electronic Annotation more info
enables bis(5'-adenosyl)-pentaphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables bis(5'-adenosyl)-pentaphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables diphosphoinositol-polyphosphate diphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables diphosphoinositol-polyphosphate diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables diphosphoinositol-polyphosphate diphosphatase activity	IEA Inferred from Electronic Annotation more info
enables endopolyphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables endopolyphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables endopolyphosphatase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphodiesterase decapping endonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables pyrophosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adenosine 5'-(hexahydrogen pentaphosphate) catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in diadenosine hexaphosphate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in diadenosine pentaphosphate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in diadenosine polyphosphate catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in diphosphoinositol polyphosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in polyphosphate catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: polyphosphatase DDP1

NP_014806.1

EC 3.6.1.10

EC 3.6.1.52

EC 3.6.1.60

Diadenosine and diphosphoinositol polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenosine hexa- and pentaphosphates; contains endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; possesses mRNA decapping activity; nudix hydrolase family member; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

642741..643307

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183582.1 → NP_014806.1 TPA: polyphosphatase DDP1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014806.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W2M1, Q99321

UniProtKB/TrEMBL

A6ZP08, B3LJJ6, C7GN61, C8ZGS4, G2WN36, N1NWP4

Conserved Domains (1) summary

cd04666
Location:33 → 174

Nudix_Hydrolase_9; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...