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    HHT1 histone H3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852295, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HHT1
    Official Full Name
    histone H3
    Primary source
    SGD:S000000214
    Locus tag
    YBR010W
    See related
    AllianceGenome:SGD:S000000214; FungiDB:YBR010W; VEuPathDB:YBR010W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    BUR5; SIN2
    Summary
    Enables cupric reductase (NADH) activity. Involved in several processes, including global genome nucleotide-excision repair; intracellular copper ion homeostasis; and rRNA transcription. Located in nucleus. Part of CENP-A containing nucleosome and replication fork protection complex. Orthologous to several human genes including H3-3A (H3.3 histone A); H3-3B (H3.3 histone B); and H3-5 (H3.5 histone). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HHT1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (256331..256741)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Flr1p Neighboring gene histone H4 Neighboring gene inorganic diphosphatase IPP1 Neighboring gene gag protein Neighboring gene gag-pol fusion protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Histone H3 serine 57 and lysine 56 interplay in transcription elongation and recovery from S-phase stress. Aslam A, et al. PLoS One, 2010 May 26. PMID 20520775, Free PMC Article
    2. Structural basis for histone H3K4me3 recognition by the N-terminal domain of the PHD finger protein Spp1. He C, et al. Biochem J, 2019 Jul 15. PMID 31253666
    3. Recognition of acetylated histone by Yaf9 regulates metabolic cycling of transcription initiation and chromatin regulatory factors. Zhang J, et al. Genes Dev, 2021 Dec 1. PMID 34819351, Free PMC Article
    4. Establishment and Maintenance of Chromatin Architecture Are Promoted Independently of Transcription by the Histone Chaperone FACT and H3-K56 Acetylation in Saccharomyces cerevisiae. McCullough LL, et al. Genetics, 2019 Mar. PMID 30679261, Free PMC Article
    5. Structure and activity of the peptidyl-prolyl isomerase domain from the histone chaperone Fpr4 toward histone H3 proline isomerization. Monneau YR, et al. J Biol Chem, 2013 Sep 6. PMID 23888048, Free PMC Article

    See all (680) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The N-Terminal Tail of Histone H3 Regulates Copper Homeostasis in Saccharomyces cerevisiae.
      Title: The N-Terminal Tail of Histone H3 Regulates Copper Homeostasis in Saccharomyces cerevisiae.
    2. Histone sumoylation promotes Set3 histone-deacetylase complex-mediated transcriptional regulation.
      Title: Histone sumoylation promotes Set3 histone-deacetylase complex-mediated transcriptional regulation.
    3. A conserved genetic interaction between Spt6 and Set2 regulates H3K36 methylation.
      Title: A conserved genetic interaction between Spt6 and Set2 regulates H3K36 methylation.
    4. Histone H3 threonine 11 phosphorylation by Sch9 and CK2 regulates chronological lifespan by controlling the nutritional stress response.
      Title: Histone H3 threonine 11 phosphorylation by Sch9 and CK2 regulates chronological lifespan by controlling the nutritional stress response.
    5. A model has been proposed wherein combined actions of Set1 and Jhd2 via modulating H3K4 methylation-demethylation together control chromatin dynamics during various facets of transcriptional regulation.
      Title: Counteracting H3K4 methylation modulators Set1 and Jhd2 co-regulate chromatin dynamics and gene transcription.
    6. Data indicate histone post-translational modifications (PTMs) enriched at a DNA double-strand break (DSB) site.
      Title: Proteomic identification of histone post-translational modifications and proteins enriched at a DNA double-strand break.
    7. Sas3 and Ada2-dependent histone H3 acetylation is required for transcription elongation at the de-repressed FLO1 gene.
      Title: Sas3 and Ada2(Gcn5)-dependent histone H3 acetylation is required for transcription elongation at the de-repressed FLO1 gene.
    8. The mutant ion at Histone H3 doesn't affect the recruitment of Pol II repressor RENT (regulator of nucleolar silencing and telophase exit) complex at the Ribosomal DNA region.
      Title: Histone H3 N-terminal acetylation sites especially K14 are important for rDNA silencing and aging.
    9. Pkc1 also enhances H3T45 phosphorylation and this modification is required for H3K56 acetylation.
      Title: Protein kinase C coordinates histone H3 phosphorylation and acetylation.
    10. results suggest that divergent amino acids within the histone H3 alpha3 helix play organismal roles in defining chromatin structure
      Title: Divergent Residues Within Histone H3 Dictate a Unique Chromatin Structure in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables cupric reductase (NADH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cupric reductase (NADH) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aerobic respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in global genome nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular copper ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sexual sporulation resulting in formation of a cellular spore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CENP-A containing nucleosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nucleosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of replication fork protection complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone H3
    NP_009564.1
    • Histone H3; core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation; H3K14 acetylation plays an important role in the unfolding of strongly positioned nucleosomes during repair of UV damage

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      256331..256741
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178358.1 → NP_009564.1  TPA: histone H3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009564.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ11, E9PAG1, P61830, Q6B1U3, Q6Q7G9
      UniProtKB/TrEMBL
      A6ZKV7, B3LND0, C7GM40, C8Z405, G2WL38, N1P868
      Conserved Domains (1) summary
      PTZ00018
      Location:1 → 136
      PTZ00018; histone H3; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61830.2

    Gene LinkOut

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