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    HCH1 Hch1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855440, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HCH1
    Official Full Name
    Hch1p
    Primary source
    SGD:S000005225
    Locus tag
    YNL281W
    See related
    AllianceGenome:SGD:S000005225; FungiDB:YNL281W; VEuPathDB:YNL281W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ATPase activator activity and protein-folding chaperone binding activity. Involved in protein folding. Located in cytoplasm and nucleus. Orthologous to human AHSA1 (activator of HSP90 ATPase activity 1) and AHSA2P (activator of HSP90 ATPase homolog 2, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HCH1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (108467..108928)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Wsc2p Neighboring gene Pop3p Neighboring gene delta(14)-sterol reductase Neighboring gene pheromone-regulated protein PRM1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hsp90 cochaperone Aha1 is a negative regulator of the Saccharomyces MAL activator and acts early in the chaperone activation pathway. Ran F, et al. J Biol Chem, 2010 Apr 30. PMID 20177068, Free PMC Article
    2. Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery. Meyer P, et al. EMBO J, 2004 Mar 24. PMID 15039704, Free PMC Article
    3. The co-chaperone Hch1 regulates Hsp90 function differently than its homologue Aha1 and confers sensitivity to yeast to the Hsp90 inhibitor NVP-AUY922. Armstrong H, et al. PLoS One, 2012. PMID 23166640, Free PMC Article
    4. The conserved NxNNWHW motif in Aha-type co-chaperones modulates the kinetics of Hsp90 ATPase stimulation. Mercier R, et al. Nat Commun, 2019 Mar 20. PMID 30894538, Free PMC Article
    5. A mutation in the catalytic loop of Hsp90 specifically impairs ATPase stimulation by Aha1p, but not Hch1p. Horvat NK, et al. J Mol Biol, 2014 Jun 12. PMID 24726918

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphorylation of human Hsp90alpha at the highly conserved tyrosine (Y) 627 affects it conformation and function. Y627 is not phosphorylated in yeast, but study demonstrated that the non-conserved yeast co-chaperone, Hch1, modifies yeast Hsp90 (Hsp82) through Y606E phosphomimetic mutation raising the possibility that this post-translational modification in higher eukaryotes represents an evolutionary substitution for ...
      Title: An Hsp90 co-chaperone protein in yeast is functionally replaced by site-specific posttranslational modification in humans.
    2. The work here suggests that both Hch1p and Aha1p regulate Hsp90 function through interaction with the catalytic loop but do so in different ways.
      Title: A mutation in the catalytic loop of Hsp90 specifically impairs ATPase stimulation by Aha1p, but not Hch1p.
    3. The co-chaperone Hch1 regulates Hsp90 function differently than its homologue Aha1 and confers sensitivity to yeast to the Hsp90 inhibitor NVP-AUY922.
      Title: The co-chaperone Hch1 regulates Hsp90 function differently than its homologue Aha1 and confers sensitivity to yeast to the Hsp90 inhibitor NVP-AUY922.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-folding chaperone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Hch1p
    NP_014118.1
    • Heat shock protein regulator; binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; role in regulating Hsp90 inhibitor drug sensitivity; GFP-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      108467..108928
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183119.1 → NP_014118.1  TPA: Hch1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014118.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0R3, P53834
      UniProtKB/TrEMBL
      A6ZRG4, B3LPC0, C7GP83, C8ZGP0, G2WLI5, N1NZV9
      Conserved Domains (1) summary
      COG5580
      Location:1 → 153
      COG5580; Activator of HSP90 ATPase [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53834.1

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