Myo1c myosin IC [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Myo1cprovided by MGI
Official Full Name: myosin ICprovided by MGI
Primary source: MGI:MGI:106612
See related: Ensembl:ENSMUSG00000017774 AllianceGenome:MGI:106612
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NMI; MMIb; myr2; MYO1E; mm1beta
Summary: This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The protein functions in intracellular vesicle transport to the plasma membrane. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in lung adult (RPKM 70.4), subcutaneous fat pad adult (RPKM 51.1) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 45.92 cM

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (75541345..75565450)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (75650519..75674643)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myosin 1c: A novel regulator of glucose uptake in brown adipocytes.
Title: Myosin 1c: A novel regulator of glucose uptake in brown adipocytes.
The regulatory protein 14-3-3beta binds to the IQ motifs of myosin-IC independent of phosphorylation.
Title: The regulatory protein 14-3-3β binds to the IQ motifs of myosin-IC independent of phosphorylation.
The motor protein Myo1c regulates transforming growth factor-beta-signaling and fibrosis in podocytes.
Title: The motor protein Myo1c regulates transforming growth factor-β-signaling and fibrosis in podocytes.
Myo1c ensembles can generate forces parallel to lipid bilayers.
Title: Force Generation by Membrane-Associated Myosin-I.
We propose a novel genome-wide mechanism where myosin synergizes with Pol II-associated actin to link the polymerase machinery with permissive chromatin for transcription activation.
Title: Nuclear myosin 1 contributes to a chromatin landscape compatible with RNA polymerase II transcription activation.
Our observations demonstrate specific changes in the expression of myosin IC isoform A that are concurrent with the occurrence of prostate cancer in the TRAMP mouse prostate cancer model that closely mimics clinical prostate cancer
Title: Selective expression of myosin IC Isoform A in mouse and human cell lines and mouse prostate cancer tissues.
Ca(2+) binding to calmodulin induces major conformational changes in both IQ motifs and the post-IQ domain and increases flexibility of the myosin-1c tail.
Title: Structure of myosin-1c tail bound to calmodulin provides insights into calcium-mediated conformational coupling.
The v-Crk-myosin-1c interaction, which modulates membrane dynamics by regulating Rac1 activity, is crucial for cell adhesion and spreading.
Title: Interaction of crk with Myosin-1c participates in fibronectin-induced cell spreading.
Mouse nuclear myosin I knock-out shows interchangeability and redundancy of myosin isoforms in the cell nucleus.
Title: Mouse nuclear myosin I knock-out shows interchangeability and redundancy of myosin isoforms in the cell nucleus.
Myo1c functions as a slow transporter rather than a tension-sensitive anchor.
Title: Myosin IC generates power over a range of loads via a new tension-sensing mechanism.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126923 (e-PCR)
- UniSTS:209764

Myo1c (e-PCR), detects polymorphism
- UniSTS:532114

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	NAS Non-traceable Author Statement more info	PubMed
enables actin binding	NAS Non-traceable Author Statement more info	PubMed
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	NAS Non-traceable Author Statement more info	PubMed
enables microfilament motor activity	EXP Inferred from Experiment more info	PubMed
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microfilament motor activity	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament-based movement	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin remodeling	NAS Non-traceable Author Statement more info	PubMed
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cellular response to insulin stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of cellular response to insulin stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein targeting to membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of protein targeting to membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase I	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of transcription by RNA polymerase III	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to membrane	IEA Inferred from Electronic Annotation more info
involved_in protein targeting to membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of bicellular tight junction assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vesicle transport along actin filament	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of B-WICH complex	ISO Inferred from Sequence Orthology more info
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in basal plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
part_of filamentous actin	IEA Inferred from Electronic Annotation more info
part_of filamentous actin	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
located_in microvillus	IEA Inferred from Electronic Annotation more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	NAS Non-traceable Author Statement more info	PubMed
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info
located_in stereocilium	IDA Inferred from Direct Assay more info	PubMed
located_in stereocilium bundle	ISO Inferred from Sequence Orthology more info
located_in stereocilium membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: unconventional myosin-Ic

Names: MMI-beta; myosin I beta; myosin-Ibeta; myosin-Ic; nuclear myosin I beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080774.2 → NP_001074243.1 unconventional myosin-Ic isoform b

See identical proteins and their annotated locations for NP_001074243.1

Status: VALIDATED

Source sequence(s)

AL591440

Consensus CDS

CCDS25054.1

UniProtKB/Swiss-Prot

Q9WTI7

Related

ENSMUSP00000099562.4, ENSMUST00000102504.10

Conserved Domains (4) summary

smart00015
Location:721 → 741

IQ; Calmodulin-binding motif

smart00242
Location:8 → 693

MYSc; Myosin. Large ATPases

cd01378
Location:27 → 683

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:839 → 1006

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
NM_001080775.2 → NP_001074244.1 unconventional myosin-Ic isoform a

See identical proteins and their annotated locations for NP_001074244.1

Status: VALIDATED

Source sequence(s)

AL591440

Consensus CDS

CCDS36228.1

UniProtKB/Swiss-Prot

Q9WTI7

Related

ENSMUSP00000104069.3, ENSMUST00000108431.3

Conserved Domains (4) summary

smart00015
Location:737 → 757

IQ; Calmodulin-binding motif

smart00242
Location:24 → 709

MYSc; Myosin. Large ATPases

cd01378
Location:43 → 699

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:855 → 1022

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
NM_001370611.2 → NP_001357540.1 unconventional myosin-Ic isoform c

Status: VALIDATED

Source sequence(s)

AL591440

Consensus CDS

CCDS88191.1

UniProtKB/Swiss-Prot

O08571, O08834, Q3TBQ4, Q3U231, Q5ND46, Q5ND48, Q5ND49, Q9ERB6, Q9QW54, Q9WTI7

Related

ENSMUSP00000099563.4, ENSMUST00000102505.10

Conserved Domains (3) summary

smart00015
Location:756 → 776

IQ; Calmodulin-binding motif

cd01378
Location:62 → 718

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:874 → 1038

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
NM_008659.4 → NP_032685.1 unconventional myosin-Ic isoform b

See identical proteins and their annotated locations for NP_032685.1

Status: VALIDATED

Source sequence(s)

AL591440

Consensus CDS

CCDS25054.1

UniProtKB/Swiss-Prot

Q9WTI7

Related

ENSMUSP00000070388.7, ENSMUST00000069057.13

Conserved Domains (4) summary

smart00015
Location:721 → 741

IQ; Calmodulin-binding motif

smart00242
Location:8 → 693

MYSc; Myosin. Large ATPases

cd01378
Location:27 → 683

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:839 → 1006

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding