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    gmd GDP-mannose 4,6-dehydratase [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 883089, updated on 24-Aug-2024

    Summary

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    Gene symbol
    gmd
    Gene description
    GDP-mannose 4,6-dehydratase
    Locus tag
    PA5453
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (6143109..6144080, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene glycosyltransferase WbpX Neighboring gene ABC transporter Neighboring gene LPS efflux transporter membrane protein Neighboring gene phosphomannose isomerase/mannose-1-phosphate guanylyl transferase Neighboring gene oxidoreductase Rmd Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene acyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Prevalence of gca, a gene involved in synthesis of A-band common antigen polysaccharide in Pseudomonas aeruginosa. Currie HL, et al. Clin Diagn Lab Immunol, 1995 Sep. PMID 8548534, Free PMC Article
    2. The structural basis for catalytic function of GMD and RMD, two closely related enzymes from the GDP-D-rhamnose biosynthesis pathway. King JD, et al. FEBS J, 2009 May. PMID 19459932, Free PMC Article
    3. Synthesis of the A-band polysaccharide sugar D-rhamnose requires Rmd and WbpW: identification of multiple AlgA homologues, WbpW and ORF488, in Pseudomonas aeruginosa. Rocchetta HL, et al. Mol Microbiol, 1998 Sep. PMID 9781879
    4. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
    5. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables GDP-mannose 4,6-dehydratase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within GDP-D-rhamnose biosynthetic process EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within O antigen biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within lipopolysaccharide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GDP-mannose 4,6-dehydratase
    NP_254140.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      6143109..6144080 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_254140.1 GDP-mannose 4,6-dehydratase [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_254140.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q51366
      Conserved Domains (1) summary
      COG1089
      Location:1 → 323
      Gmd; GDP-D-mannose dehydratase [Cell wall/membrane/envelope biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q51366.2

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