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    drongo drongo [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33263, updated on 27-Dec-2024

    Summary

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    Official Symbol
    drongoprovided by FlyBase
    Official Full Name
    drongoprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020304
    Locus tag
    Dmel_CG3365
    See related
    AllianceGenome:FB:FBgn0020304
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3365; Dmel\CG3365; DRONGO
    Summary
    Predicted to enable GTPase activator activity. Located in cell cortex. Is expressed in several structures, including anlage in statu nascendi; antennal anlage; antennal primordium; central brain anlage; and head epidermis primordium. Orthologous to human AGFG1 (ArfGAP with FG repeats 1) and AGFG2 (ArfGAP with FG repeats 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See drongo in Genome Data Viewer
    Location:
    21E2-21E2; 2-1.5 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (833584..851071, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (833584..851071, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene dreadlocks Neighboring gene long non-coding RNA:CR44060 Neighboring gene uncharacterized protein Neighboring gene kraken

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Organization patterns of the AGFG genes: an evolutionary study. Panaro MA, et al. Immunopharmacol Immunotoxicol, 2011 Mar. PMID 21284487
    2. The temporally controlled expression of Drongo, the fruit fly homolog of AGFG1, is achieved in female germline cells via P-bodies and its localization requires functional Rab11. Catrina IE, et al. RNA Biol, 2016 Nov. PMID 27654348, Free PMC Article
    3. A genome-wide enhancer/suppressor screen for Dube3a interacting genes in Drosophila melanogaster. Hope KA, et al. Sci Rep, 2019 Feb 20. PMID 30787400, Free PMC Article
    4. Genome-wide identification of direct targets of the Drosophila retinal determination protein Eyeless. Ostrin EJ, et al. Genome Res, 2006 Apr. PMID 16533912, Free PMC Article
    5. Exploiting position effects and the gypsy retrovirus insulator to engineer precisely expressed transgenes. Markstein M, et al. Nat Genet, 2008 Apr. PMID 18311141, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The ArfGAP Drongo Promotes Actomyosin Contractility during Collective Cell Migration by Releasing Myosin Phosphatase from the Trailing Edge.
      Title: The ArfGAP Drongo Promotes Actomyosin Contractility during Collective Cell Migration by Releasing Myosin Phosphatase from the Trailing Edge.
    2. Report shows the expression pattern for Drongo during oogenesis, identifying a temporally controlled Drongo expression achieved by translational repression of drongo mRNA in P-bodies. Its proper localization at the oocyte's cortex during mid-oogenesis requires functional Rab11.
      Title: The temporally controlled expression of Drongo, the fruit fly homolog of AGFG1, is achieved in female germline cells via P-bodies and its localization requires functional Rab11.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    drongo
    Names
    CG3365-PC
    CG3365-PF
    CG3365-PG
    CG3365-PH
    CG3365-PI
    drongo-PC
    drongo-PF
    drongo-PG
    drongo-PH
    drongo-PI

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      833584..851071 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057891.3 → NP_477239.2  drongo, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477239.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96639, Q9VPU3
      Conserved Domains (1) summary
      pfam01412
      Location:15 → 126
      ArfGap; Putative GTPase activating protein for Arf

    2. NM_001169377.1 → NP_001162848.1  drongo, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162848.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHR0
      Conserved Domains (1) summary
      pfam01412
      Location:15 → 126
      ArfGap; Putative GTPase activating protein for Arf

    3. NM_001169378.2 → NP_001162849.1  drongo, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162849.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHR1
      Conserved Domains (1) summary
      cl02464
      Location:1 → 56
      ArfGap; Putative GTPase activating protein for Arf

    4. NM_164392.3 → NP_722660.1  drongo, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722660.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96639, Q8MRM4
      Related
      FBpp0077701
      Conserved Domains (1) summary
      cl02464
      Location:1 → 56
      ArfGap; Putative GTPase activating protein for Arf

    5. NM_001144291.2 → NP_001137763.2  drongo, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137763.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z005, O96639
      Conserved Domains (1) summary
      pfam01412
      Location:15 → 126
      ArfGap; Putative GTPase activating protein for Arf
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z005 B7Z005
    E1JHR0 E1JHR0
    E1JHR1 E1JHR1
    O96639 O96639
    Q8MRM4 Q8MRM4
    Q9VPU3 Q9VPU3

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