Hen1 Hen1 methyltransferase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hen1provided by FlyBase
Official Full Name: Hen1 methyltransferaseprovided by FlyBase
Primary source: FLYBASE:FBgn0033686
Locus tag: Dmel_CG12367
See related: AllianceGenome:FB:FBgn0033686
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12367; Dmel\CG12367; DmHen1; FBgn 33686; hen-1; Hen-1; hen1; Pimet; PIMET; Pimet/DmHen1
Summary: Enables small RNA 2'-O-methyltransferase activity. Involved in RNA methylation and negative regulation of gene expression. Predicted to be active in cytoplasm and nucleus. Is expressed in organism; ovary; and testis. Orthologous to human HENMT1 (HEN methyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (12145710..12152752)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (8033215..8040257)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

antagonistic roles of Nbr and Hen1 define a mechanism to modulate piRNA 3' ends.
Title: Antagonistic roles of Nibbler and Hen1 in modulating piRNA 3' ends in Drosophila.
study found that DmHen1, the Drosophila homolog of HEN1, methylates the termini of siRNAs and piRNAsmethylates the termini of siRNAs and piRNAs.
Title: The Drosophila RNA methyltransferase, DmHen1, modifies germline piRNAs and single-stranded siRNAs in RISC.
Pimet mediates piwi-interacting RNAs 2'-O-methylation in Drosophila.
Title: Pimet, the Drosophila homolog of HEN1, mediates 2'-O-methylation of Piwi- interacting RNAs at their 3' ends.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables O-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables O-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables RNA methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables small RNA 2'-O-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables small RNA 2'-O-methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA methylation	IDA Inferred from Direct Assay more info	PubMed
involved_in RNA methylation	IEA Inferred from Electronic Annotation more info
involved_in RNA methylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in piRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in piRNA processing	IDA Inferred from Direct Assay more info	PubMed
involved_in piRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in primary piRNA processing	TAS Traceable Author Statement more info	PubMed
involved_in secondary piRNA processing	TAS Traceable Author Statement more info	PubMed
involved_in siRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in siRNA processing	IDA Inferred from Direct Assay more info	PubMed
involved_in transposable element silencing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

NP_610732.1

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The following sections contain reference sequences that belong to a specific genome build. Explain