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    CG33172 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32526, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG33172provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0053172
    Locus tag
    Dmel_CG33172
    See related
    AllianceGenome:FB:FBgn0053172
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8473; Dmel\CG33172
    Summary
    Predicted to enable enzyme regulator activity and tRNA binding activity. Predicted to be involved in negative regulation of cell population proliferation and wobble position ribose methylation. Predicted to be active in cytoplasm. Orthologous to human WDR6 (WD repeat domain 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG33172 in Genome Data Viewer
    Location:
    13E15-13E16; 1-51 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15769664..15772985)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15663697..15667018)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L3 Neighboring gene RNA polymerase III subunit A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene EF-hand domain containing 1.1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. tRNA 2'-O-methylation by a duo of TRM7/FTSJ1 proteins modulates small RNA silencing in Drosophila. Angelova MT, et al. Nucleic Acids Res, 2020 Feb 28. PMID 31943105, Free PMC Article
    2. Conserved genes act as modifiers of invertebrate SMN loss of function defects. Dimitriadi M, et al. PLoS Genet, 2010 Oct 28. PMID 21124729, Free PMC Article
    3. Modeling spinal muscular atrophy in Drosophila. Chang HC, et al. PLoS One, 2008 Sep 15. PMID 18791638, Free PMC Article
    4. A neurogenetic mechanism of experience-dependent suppression of aggression. Ishii K, et al. Sci Adv, 2022 Sep 9. PMID 36070378, Free PMC Article
    5. The genetics of egg retention and fertilization success in Drosophila: One step closer to understanding the transition from facultative to obligate viviparity. Horváth B, et al. Evolution, 2018 Feb. PMID 29265369

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables enzyme regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in wobble position ribose methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG33172-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15769664..15772985
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176738.2 → NP_788911.2  uncharacterized protein Dmel_CG33172 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788911.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C4XVK4, Q86B53
      Conserved Domains (3) summary
      COG2319
      Location:29 → 320
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:206 → 250
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:197 → 316
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86B53 Q86B53

    Gene LinkOut

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