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    CG2681 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31258, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG2681provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024997
    Locus tag
    Dmel_CG2681
    See related
    AllianceGenome:FB:FBgn0024997
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    100G10.2; Dmel\CG2681; EG:100G10.2
    Summary
    Predicted to enable ubiquitin conjugating enzyme binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG2681 in Genome Data Viewer
    Location:
    3B2-3B3; 1-1.5 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2708684..2711668)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2602717..2605701)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene UDP-galactose transporter Neighboring gene eukaryotic translation initiation factor 2B subunit beta Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hitchhiking mapping: a population-based fine-mapping strategy for adaptive mutations in Drosophilamelanogaster. Harr B, et al. Proc Natl Acad Sci U S A, 2002 Oct 1. PMID 12351680, Free PMC Article
    2. Linkage disequilibrium patterns across a recombination gradient in African Drosophila melanogaster. Andolfatto P, et al. Genetics, 2003 Nov. PMID 14668383, Free PMC Article
    3. Comprehensively surveying structure and function of RING domains from Drosophila melanogaster. Ying M, et al. PLoS One, 2011. PMID 21912646, Free PMC Article
    4. Polyglutamine Atrophin provokes neurodegeneration in Drosophila by repressing fat. Napoletano F, et al. EMBO J, 2011 Mar 2. PMID 21278706, Free PMC Article
    5. From first base: the sequence of the tip of the X chromosome of Drosophila melanogaster, a comparison of two sequencing strategies. Benos PV, et al. Genome Res, 2001 May. PMID 11337470, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG2681-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2708684..2711668
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130666.2 → NP_570022.2  uncharacterized protein Dmel_CG2681 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_570022.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W4W4
      Related
      FBpp0070458, FBtr0070480
      Conserved Domains (2) summary
      cd00162
      Location:206 → 244
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam03145
      Location:248 → 442
      Sina; Seven in absentia protein family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76862 O76862
    Q8IH73 Q8IH73
    Q8MM55 Q8MM55
    Q8MM56 Q8MM56
    Q8MTX7 Q8MTX7
    Q8MTX8 Q8MTX8
    Q9W4W4 Q9W4W4

    Gene LinkOut

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