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    PIG-U Phosphatidylinositol glycan anchor biosynthesis class U [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34185, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PIG-Uprovided by FlyBase
    Official Full Name
    Phosphatidylinositol glycan anchor biosynthesis class Uprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032052
    Locus tag
    Dmel_CG13089
    See related
    AllianceGenome:FB:FBgn0032052
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13089; Dmel\CG13089; PIGU
    Summary
    Involved in GPI anchor biosynthetic process. Part of GPI-anchor transamidase complex. Is active in endoplasmic reticulum and nuclear membrane. Is expressed in adult head and organism. Orthologous to human PIGU (phosphatidylinositol glycan anchor biosynthesis class U). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PIG-U in Genome Data Viewer
    Location:
    29D4-29D4; 2-33 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8515096..8516755)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8515096..8516755)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L51 Neighboring gene Ubiquitin-like activating enzyme 4 Neighboring gene Sgroppino

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stability of the transamidase complex catalyzing GPI anchoring of proteins. Kawaguchi K, et al. Biochem Biophys Res Commun, 2019 May 7. PMID 30914202
    2. Subunits of the GPI transamidase complex localize to the endoplasmic reticulum and nuclear envelope in Drosophila. Kawaguchi K, et al. FEBS Lett, 2021 Apr. PMID 33496978
    3. Drosophila TDP-43 RNA-Binding Protein Facilitates Association of Sister Chromatid Cohesion Proteins with Genes, Enhancers and Polycomb Response Elements. Swain A, et al. PLoS Genet, 2016 Sep. PMID 27662615, Free PMC Article
    4. Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep. Palermo J, et al. Sci Adv, 2023 Jan 6. PMID 36608130, Free PMC Article
    5. Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response. Hollien J, et al. Science, 2006 Jul 7. PMID 16825573

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in attachment of GPI anchor to protein IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in attachment of GPI anchor to protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of GPI-anchor transamidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GPI-anchor transamidase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of GPI-anchor transamidase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphatidylinositol glycan anchor biosynthesis class U
    Names
    CG13089-PA
    PIG-U-PA
    phosphatidylinositol glycan anchor biosynthesis, class U
    phosphatidylinositol glycan anchor biosynthesis, class U ortholog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8515096..8516755
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135394.3 → NP_609238.1  phosphatidylinositol glycan anchor biosynthesis class U [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609238.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VLK0
      Related
      FBpp0079294
      Conserved Domains (1) summary
      pfam06728
      Location:10 → 386
      PIG-U; GPI transamidase subunit PIG-U
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VLK0 Q9VLK0

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