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    rau rau [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33814, updated on 17-Dec-2024

    Summary

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    Official Symbol
    rauprovided by FlyBase
    Official Full Name
    rauprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031745
    Locus tag
    Dmel_CG8965
    See related
    AllianceGenome:FB:FBgn0031745
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8965; Dmel\CG8965
    Summary
    Enables protein homodimerization activity and small GTPase binding activity. Involved in neurogenesis and positive regulation of signal transduction. Is expressed in several structures, including anlage in statu nascendi; ganglia; glial cell; gut section; and head epidermis primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rau in Genome Data Viewer
    Location:
    26A1-26A1; 2-18 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5859769..5879498, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5859769..5879498, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Cytochrome c oxidase subunit 6C-like Neighboring gene Trissin receptor Neighboring gene uncharacterized protein Neighboring gene Seminal fluid protein 26Ac

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila melanogaster Zelda and Single-minded collaborate to regulate an evolutionarily dynamic CNS midline cell enhancer. Pearson JC, et al. Dev Biol, 2012 Jun 15. PMID 22537497, Free PMC Article
    2. Female influence on pre- and post-copulatory sexual selection and its genetic basis in Drosophila melanogaster. Giardina TJ, et al. Mol Ecol, 2011 Oct. PMID 21902747, Free PMC Article
    3. FGF signaling directs myotube guidance by regulating Rac activity. Yang S, et al. Development, 2020 Feb 7. PMID 31932350, Free PMC Article
    4. Antagonistic feedback loops involving Rau and Sprouty in the Drosophila eye control neuronal and glial differentiation. Sieglitz F, et al. Sci Signal, 2013 Nov 5. PMID 24194583
    5. Direct estimation of per nucleotide and genomic deleterious mutation rates in Drosophila. Haag-Liautard C, et al. Nature, 2007 Jan 4. PMID 17203060

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deletion of rau in flies decreased the differentiation of retinal wrapping glia and induced a rough eye phenotype, similar to that seen in alterations of Ras signaling.
      Title: Antagonistic feedback loops involving Rau and Sprouty in the Drosophila eye control neuronal and glial differentiation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in R7 cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glial cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of epidermal growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of fibroblast growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rau
    Names
    CG8965-PA
    CG8965-PB
    rau-PA
    rau-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      5859769..5879498 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135121.3 → NP_608965.1  rau, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608965.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VML8
      Related
      FBpp0078789
      Conserved Domains (2) summary
      pfam00788
      Location:60 → 154
      RA; Ras association (RalGDS/AF-6) domain
      cl00155
      Location:154 → 245
      UBQ; Ubiquitin-like proteins

    2. NM_001298713.1 → NP_001285642.1  rau, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285642.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VML8
      Conserved Domains (2) summary
      pfam00788
      Location:60 → 154
      RA; Ras association (RalGDS/AF-6) domain
      cl00155
      Location:154 → 245
      UBQ; Ubiquitin-like proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VML8 Q9VML8

    Gene LinkOut

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