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    Menl-2 Malic enzyme like-2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3772692, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Menl-2provided by FlyBase
    Official Full Name
    Malic enzyme like-2provided by FlyBase
    Primary source
    FLYBASE:FBgn0029153
    Locus tag
    Dmel_CG7969
    See related
    AllianceGenome:FB:FBgn0029153
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG30097; CG7969; Dmel\CG7969
    Summary
    Predicted to enable malate dehydrogenase (decarboxylating) (NADP+) activity. Predicted to be involved in malate metabolic process and pyruvate metabolic process. Predicted to be active in mitochondrion. Is expressed in spermatozoon. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Menl-2 in Genome Data Viewer
    Location:
    53C4-53C4; 2-80 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16414815..16419398, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12302320..12306903, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45316 Neighboring gene long non-coding RNA:CR45317 Neighboring gene uncharacterized protein Neighboring gene Semaphorin 2b Neighboring gene Malic enzyme like-1 Neighboring gene uncharacterized protein Neighboring gene jetboil

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genomic signatures of globally enhanced gene duplicate accumulation in the megadiverse higher Diptera fueling intralocus sexual conflict resolution. Bao R, et al. PeerJ, 2020. PMID 33083121, Free PMC Article
    2. Dietary Sugar Shifts Mitochondrial Metabolism and Small RNA Biogenesis in Sperm. Ramesh R, et al. Antioxid Redox Signal, 2023 Jun. PMID 36509450, Free PMC Article
    3. Genetic Architecture of Abdominal Pigmentation in Drosophila melanogaster. Dembeck LM, et al. PLoS Genet, 2015 May. PMID 25933381, Free PMC Article
    4. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
    5. High-fidelity promoter profiling reveals widespread alternative promoter usage and transposon-driven developmental gene expression. Batut P, et al. Genome Res, 2013 Jan. PMID 22936248, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables malate dehydrogenase (decarboxylating) (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables malic enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in malate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyruvate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    malic enzyme like-2
    Names
    CG7969-PA
    CG7969-PD
    CG7969-PE
    Menl-2-PA
    Menl-2-PD
    Menl-2-PE
    NP_001027424.2
    NP_001027425.1
    NP_001163167.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16414815..16419398 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001032253.2 → NP_001027424.2  malic enzyme like-2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027424.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAF6, A1ZAF7, Q9U1J2, Q9V7P6
      Conserved Domains (3) summary
      PLN03129
      Location:8 → 573
      PLN03129; NADP-dependent malic enzyme; Provisional
      pfam00390
      Location:102 → 283
      malic; Malic enzyme, N-terminal domain
      cl21454
      Location:293 → 567
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_001032254.3 → NP_001027425.1  malic enzyme like-2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027425.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAF6, A1ZAF7, Q9U1J2, Q9V7P6
      Conserved Domains (3) summary
      PLN03129
      Location:8 → 573
      PLN03129; NADP-dependent malic enzyme; Provisional
      pfam00390
      Location:102 → 283
      malic; Malic enzyme, N-terminal domain
      cl21454
      Location:293 → 567
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    3. NM_001169696.1 → NP_001163167.1  malic enzyme like-2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163167.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T4C6, Q9U1J2, Q9V7P6
      Conserved Domains (3) summary
      PLN03129
      Location:8 → 531
      PLN03129; NADP-dependent malic enzyme; Provisional
      pfam00390
      Location:60 → 241
      malic; Malic enzyme, N-terminal domain
      cl21454
      Location:251 → 525
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZAF6 A1ZAF6
    Q8T4C6 Q8T4C6
    Q9U1J2 Q9U1J2

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