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    Ptpmeg Protein tyrosine phosphatase Meg [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38059, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ptpmegprovided by FlyBase
    Official Full Name
    Protein tyrosine phosphatase Megprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261985
    Locus tag
    Dmel_CG1228
    See related
    AllianceGenome:FB:FBgn0261985
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.211; CG1228; dMEG1; Dmel\CG1228; dptpmeg; dPtpmeg; Meg; MEG1; ptmpeg; PTP-meg; ptpmeg; PTPMEG; scc
    Summary
    Enables non-membrane spanning protein tyrosine phosphatase activity. Involved in several processes, including negative regulation of border follicle cell migration; nervous system development; and thermosensory behavior. Located in cytosol. Is expressed in several structures, including adult brain cell body rind; embryonic/larval midgut primordium; ganglia; head epidermis primordium; and sensory nervous system primordium. Orthologous to human PTPN3 (protein tyrosine phosphatase non-receptor type 3) and PTPN4 (protein tyrosine phosphatase non-receptor type 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ptpmeg in Genome Data Viewer
    Location:
    61C1-61C1; 3-0.5 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (328097..356050)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (328097..356050)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ada2a-containing complex component 3 Neighboring gene methuselah-like 9 Neighboring gene methuselah-like 10 Neighboring gene methuselah Neighboring gene uncharacterized protein Neighboring gene Regulator of cullins 1b Neighboring gene Cell division cycle 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparative analysis of the Band 4.1/ezrin-related protein tyrosine phosphatase Pez from two Drosophila species: implications for structure and function. Edwards K, et al. Gene, 2001 Sep 19. PMID 11587846
    2. Ptpmeg is required for the proper establishment and maintenance of axon projections in the central brain of Drosophila. Whited JL, et al. Development, 2007 Jan. PMID 17138662
    3. Transcriptional regulation of the methuselah gene by dorsal protein in Drosophila melanogaster. Kim H, et al. Mol Cells, 2006 Apr 30. PMID 16682822
    4. Protein tyrosine phosphatase PTPN3 inhibits lung cancer cell proliferation and migration by promoting EGFR endocytic degradation. Li MY, et al. Oncogene, 2015 Jul. PMID 25263444
    5. PTPN9-mediated dephosphorylation of VTI1B promotes ATG16L1 precursor fusion and autophagosome formation. Chou HY, et al. Autophagy, 2021 Oct. PMID 33112705, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ptpmeg is required for the proper establishment and maintenance of axon projections in the central brain.
      Title: Ptpmeg is required for the proper establishment and maintenance of axon projections in the central brain of Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon extension involved in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in central complex development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mushroom body development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thermosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein tyrosine phosphatase Meg
    Names
    CG1228-PG
    CG1228-PH
    CG1228-PI
    CG1228-PJ
    CG1228-PK
    Meg
    Ptpmeg-PG
    Ptpmeg-PH
    Ptpmeg-PI
    Ptpmeg-PJ
    Ptpmeg-PK
    split central complex
    NP_001163309.2
    NP_001163310.2
    NP_612031.3
    NP_728522.2
    NP_728523.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      328097..356050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167831.3 → NP_728523.2  protein tyrosine phosphatase Meg, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728523.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5RJQ9, Q8WSF2, Q9W0R3
      Conserved Domains (8) summary
      smart00295
      Location:35 → 232
      B41; Band 4.1 homologues
      cd00047
      Location:668 → 955
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:502 → 589
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:226 → 320
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      pfam00102
      Location:666 → 955
      Y_phosphatase; Protein-tyrosine phosphatase
      pfam00373
      Location:125 → 232
      FERM_M; FERM central domain
      pfam08736
      Location:333 → 369
      FA; FERM adjacent (FA)
      pfam09379
      Location:38 → 102
      FERM_N; FERM N-terminal domain

    2. NM_167830.4 → NP_728522.2  protein tyrosine phosphatase Meg, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728522.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5RJQ9, Q8WSF2, Q9W0R3
      Conserved Domains (8) summary
      smart00295
      Location:35 → 232
      B41; Band 4.1 homologues
      cd00047
      Location:668 → 955
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:502 → 589
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:226 → 320
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      pfam00102
      Location:666 → 955
      Y_phosphatase; Protein-tyrosine phosphatase
      pfam00373
      Location:125 → 232
      FERM_M; FERM central domain
      pfam08736
      Location:333 → 369
      FA; FERM adjacent (FA)
      pfam09379
      Location:38 → 102
      FERM_N; FERM N-terminal domain

    3. NM_001169839.3 → NP_001163310.2  protein tyrosine phosphatase Meg, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163310.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5RJQ9, Q8WSF2, Q9W0R3
      Conserved Domains (8) summary
      smart00295
      Location:35 → 232
      B41; Band 4.1 homologues
      cd00047
      Location:668 → 955
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:502 → 589
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:226 → 320
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      pfam00102
      Location:666 → 955
      Y_phosphatase; Protein-tyrosine phosphatase
      pfam00373
      Location:125 → 232
      FERM_M; FERM central domain
      pfam08736
      Location:333 → 369
      FA; FERM adjacent (FA)
      pfam09379
      Location:38 → 102
      FERM_N; FERM N-terminal domain

    4. NM_001169838.3 → NP_001163309.2  protein tyrosine phosphatase Meg, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163309.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5RJQ9, Q8WSF2, Q9W0R3
      Conserved Domains (8) summary
      smart00295
      Location:35 → 232
      B41; Band 4.1 homologues
      cd00047
      Location:668 → 955
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:502 → 589
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:226 → 320
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      pfam00102
      Location:666 → 955
      Y_phosphatase; Protein-tyrosine phosphatase
      pfam00373
      Location:125 → 232
      FERM_M; FERM central domain
      pfam08736
      Location:333 → 369
      FA; FERM adjacent (FA)
      pfam09379
      Location:38 → 102
      FERM_N; FERM N-terminal domain

    5. NM_138187.4 → NP_612031.3  protein tyrosine phosphatase Meg, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612031.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5RJQ9, Q8WSF2, Q9W0R3
      Conserved Domains (8) summary
      smart00295
      Location:35 → 232
      B41; Band 4.1 homologues
      cd00047
      Location:668 → 955
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:502 → 589
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:226 → 320
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      pfam00102
      Location:666 → 955
      Y_phosphatase; Protein-tyrosine phosphatase
      pfam00373
      Location:125 → 232
      FERM_M; FERM central domain
      pfam08736
      Location:333 → 369
      FA; FERM adjacent (FA)
      pfam09379
      Location:38 → 102
      FERM_N; FERM N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86PA5 Q86PA5
    Q8IRJ0 Q8IRJ0
    Q8WSF2 Q8WSF2
    Q9NHZ3 Q9NHZ3
    Q9W0R3 Q9W0R3

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