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    CG10962 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31824, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG10962provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030073
    Locus tag
    Dmel_CG10962
    See related
    AllianceGenome:FB:FBgn0030073
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7090; Dmel\CG10962
    Summary
    Predicted to enable 3-keto sterol reductase activity and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Is expressed in several structures, including gut section; larval visceral muscle cell; and wing disc. Orthologous to human DHRS11 (dehydrogenase/reductase 11). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10962 in Genome Data Viewer
    Location:
    8C1-8C1; 1-26 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8972908..8974255, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8866941..8868288, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene retinal degeneration A Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43836 Neighboring gene mir-4964 stem loop Neighboring gene uncharacterized protein Neighboring gene mir-31b stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression profiling of Drosophila imaginal discs. Klebes A, et al. Genome Biol, 2002 Jul 24. PMID 12186645, Free PMC Article
    2. Joint estimates of quantitative trait locus effect and frequency using synthetic recombinant populations of Drosophila melanogaster. Macdonald SJ, et al. Genetics, 2007 Jun. PMID 17435224, Free PMC Article
    3. Clueless, a conserved Drosophila gene required for mitochondrial subcellular localization, interacts genetically with parkin. Cox RT, et al. Dis Model Mech, 2009 Sep-Oct. PMID 19638420, Free PMC Article
    4. Female Genetic Contributions to Sperm Competition in Drosophila melanogaster. Chen DS, et al. Genetics, 2019 Jul. PMID 31101677, Free PMC Article
    5. Divergent transcriptomic responses to repeated and single cold exposures in Drosophila melanogaster. Zhang J, et al. J Exp Biol, 2011 Dec 1. PMID 22071194

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 17-beta-ketosteroid reductase (NADPH) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 3-keto sterol reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10962-PB
    NP_788887.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      8972908..8974255 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176714.3 → NP_788887.1  uncharacterized protein Dmel_CG10962 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788887.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IRN0, Q95R56
      Related
      FBpp0071206
      Conserved Domains (2) summary
      COG4221
      Location:1 → 249
      YdfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [Energy production and conversion]
      cl21454
      Location:1 → 243
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IRN0 Q8IRN0
    Q95R56 Q95R56

    Gene LinkOut

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