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    Arv1 ACAT-related protein required for viability 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 318031, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arv1provided by FlyBase
    Official Full Name
    ACAT-related protein required for viability 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0052442
    Locus tag
    Dmel_CG32442
    See related
    AllianceGenome:FB:FBgn0052442
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE62711; BcDNA:RH17480; CG32442; Dmel\CG32442
    Summary
    Involved in positive regulation of cell division. Predicted to be active in Golgi apparatus and cortical endoplasmic reticulum. Is expressed in organism. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 38. Orthologous to human ARV1 (ARV1 homolog, fatty acid homeostasis modulator). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Arv1 in Genome Data Viewer
    Location:
    78D5-78D5; 3-47 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21528218..21529333, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21521318..21522433, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cyclin-dependent kinase 12 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43877 Neighboring gene Makorin 1 Neighboring gene pickpocket 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arv1 promotes cell division by recruiting IQGAP1 and myosin to the cleavage furrow. Sundvold H, et al. Cell Cycle, 2016. PMID 27104745, Free PMC Article
    2. Makorin 1 Regulates Developmental Timing in Drosophila. Tran HT, et al. Mol Cells, 2018 Dec 31. PMID 30396233, Free PMC Article
    3. Impaired retrograde transport by the Dynein/Dynactin complex contributes to Tau-induced toxicity. Butzlaff M, et al. Hum Mol Genet, 2015 Jul 1. PMID 25794683
    4. Investigating Developmental and Epileptic Encephalopathy Using Drosophila melanogaster. Takai A, et al. Int J Mol Sci, 2020 Sep 3. PMID 32899411, Free PMC Article
    5. Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. Pospisilik JA, et al. Cell, 2010 Jan 8. PMID 20074523

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in intracellular sterol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular sterol transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of plasma membrane sterol distribution IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingolipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sterol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cortical endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ACAT-related protein required for viability 1
    Names
    Arv1-PA
    Arv1-PB
    Arv1-PC
    CG32442-PA
    CG32442-PB
    CG32442-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21528218..21529333 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168920.3 → NP_730651.1  ACAT-related protein required for viability 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730651.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYH1
      Related
      FBpp0088739
      Conserved Domains (1) summary
      pfam04161
      Location:8 → 194
      Arv1; Arv1-like family

    2. NM_001144523.3 → NP_001137995.1  ACAT-related protein required for viability 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137995.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z097, Q8IGH7
      Conserved Domains (1) summary
      cl21705
      Location:8 → 68
      Arv1; Arv1-like family

    3. NM_168921.3 → NP_730652.1  ACAT-related protein required for viability 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730652.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGH7, Q8IPT3
      Related
      FBpp0088738
      Conserved Domains (1) summary
      cl21705
      Location:8 → 68
      Arv1; Arv1-like family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z097 B7Z097
    Q8IGH7 Q8IGH7
    Q8IPT3 Q8IPT3
    Q8SYH1 Q8SYH1

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