U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Akr1B Aldo-keto reductase 1B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39304, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Akr1Bprovided by FlyBase
    Official Full Name
    Aldo-keto reductase 1Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0086254
    Locus tag
    Dmel_CG6084
    See related
    AllianceGenome:FB:FBgn0086254
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    34F4T; AR; CG6084; dAR1; Dmel\CG6084; ESTS:34F4T
    Summary
    Enables aldose reductase (NADPH) activity. Involved in fructose biosynthetic process and sorbitol biosynthetic process. Located in extracellular space. Is expressed in several structures, including adult brain cell body rind; adult head; adult heart; follicle cell; and germline cell. Human ortholog(s) of this gene implicated in several diseases, including arteriosclerosis; congenital bile acid synthesis defect 2; diabetic neuropathy; diabetic retinopathy; and type 2 diabetes mellitus. Orthologous to several human genes including AKR1B1 (aldo-keto reductase family 1 member B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Akr1B in Genome Data Viewer
    Location:
    68C15-68C15; 3-36 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11620535..11624381, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11613635..11617481, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Mucin 68Ca Neighboring gene uncharacterized protein Neighboring gene PCI domain-containing protein 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Specific prostaglandins are produced in the migratory cells and the surrounding substrate to promote Drosophila border cell migration. Mellentine SQ, et al. Front Cell Dev Biol, 2023. PMID 38283991, Free PMC Article
    2. Global analysis of positive and negative pre-mRNA splicing regulators in Drosophila. Blanchette M, et al. Genes Dev, 2005 Jun 1. PMID 15937219, Free PMC Article
    3. Sugar Alcohols of Polyol Pathway Serve as Alarmins to Mediate Local-Systemic Innate Immune Communication in Drosophila. Yang S, et al. Cell Host Microbe, 2019 Aug 14. PMID 31350199
    4. The polyol pathway is an evolutionarily conserved system for sensing glucose uptake. Sano H, et al. PLoS Biol, 2022 Jun. PMID 35687590, Free PMC Article
    5. Identifying calpain substrates in intact S2 cells of Drosophila. Bozoky Z, et al. Arch Biochem Biophys, 2009 Jan 15. PMID 19038228

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-glucuronate reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables aldose reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldose reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-glucuronate catabolic process to D-xylulose 5-phosphate ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fructose biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in polyol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sorbitol biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Aldo-keto reductase 1B
    Names
    Akr1B-PA
    Akr1B-PB
    Akr1B-PC
    Akr1B-PD
    Aldo/keto reductase
    CG6084-PA
    CG6084-PB
    CG6084-PC
    CG6084-PD
    aldehyde reductase
    aldose reductase
    NP_001261716.1
    NP_001261717.1
    NP_648484.1
    NP_729726.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11620535..11624381 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274787.1 → NP_001261716.1  Aldo-keto reductase 1B, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261716.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9PF61, M9PI17, Q8IQF8, Q9VTK9
      Conserved Domains (2) summary
      COG0656
      Location:38 → 316
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:45 → 248
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

    2. NM_168467.2 → NP_729726.1  Aldo-keto reductase 1B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729726.1

      Status: REVIEWED

      Related
      FBpp0075869
      Conserved Domains (2) summary
      COG0656
      Location:38 → 316
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:45 → 248
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

    3. NM_140227.2 → NP_648484.1  Aldo-keto reductase 1B, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648484.1

      Status: REVIEWED

      Related
      FBpp0075870
      Conserved Domains (2) summary
      COG0656
      Location:1 → 282
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:9 → 214
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

    4. NM_001274788.1 → NP_001261717.1  Aldo-keto reductase 1B, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261717.1

      Status: REVIEWED

      Conserved Domains (2) summary
      COG0656
      Location:1 → 282
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:9 → 214
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PF61 M9PF61
    M9PI17 M9PI17
    Q8IQF8 Q8IQF8
    Q9VTK9 Q9VTK9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous