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    DnaJ-H DnaJ homolog [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34707, updated on 17-Dec-2024

    Summary

    Official Symbol
    DnaJ-Hprovided by FlyBase
    Official Full Name
    DnaJ homologprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032474
    Locus tag
    Dmel_CG9828
    See related
    AllianceGenome:FB:FBgn0032474
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9828; dDnaJ-H; dHdj2; Dmel\CG9828; DNA J-H; dnaJ-H; DNAJ-H; NEST:bs08d07
    Summary
    Predicted to enable protein-folding chaperone binding activity. Predicted to be involved in protein refolding. Predicted to be active in cytosol. Is expressed in several structures, including adult head; embryonic/larval garland cell; embryonic/larval salivary gland; larval central nervous system; and larval ventral nerve cord. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See DnaJ-H in Genome Data Viewer
    Location:
    34A7-34A7; 2-47 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13163209..13166072, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13163209..13166072, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Protein kinase at 34A Neighboring gene kumgang Neighboring gene Sirtuin 1 Neighboring gene Scm-related gene containing four mbt domains Neighboring gene antisense RNA:CR46256 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables Hsp70 protein binding  
    enables protein-folding chaperone binding  
    enables unfolded protein binding  
    Process Evidence Code Pubs
    involved_in protein folding  
    involved_in protein refolding  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    is_active_in cytosol  

    General protein information

    Preferred Names
    DnaJ homolog
    Names
    CG9828-PA
    CG9828-PB
    CG9828-PC
    DnaJ-H-PA
    DnaJ-H-PB
    DnaJ-H-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13163209..13166072 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273502.1 → NP_001260431.1  DnaJ homolog, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260431.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PD23, Q8T922
      Conserved Domains (4) summary
      cd10719
      Location:134 → 197
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:106 → 329
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      COG0484
      Location:1 → 363
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:5 → 64
      DnaJ; DnaJ domain
    2. NM_165025.2 → NP_723785.1  DnaJ homolog, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723785.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T922, Q9VK35
      Related
      FBpp0080071
      Conserved Domains (4) summary
      cd10719
      Location:134 → 197
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:106 → 329
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      COG0484
      Location:1 → 363
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:5 → 64
      DnaJ; DnaJ domain
    3. NM_135761.3 → NP_609605.1  DnaJ homolog, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609605.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T922, Q9VK35
      Related
      FBpp0080072
      Conserved Domains (4) summary
      cd10719
      Location:134 → 197
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:106 → 329
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      COG0484
      Location:1 → 363
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:5 → 64
      DnaJ; DnaJ domain
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