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    LanB1 LanB1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34068, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LanB1provided by FlyBase
    Official Full Name
    LanB1provided by FlyBase
    Primary source
    FLYBASE:FBgn0261800
    Locus tag
    Dmel_CG7123
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD21794; beta1; CG7123; CT22015; Dmel\CG7123; EP-600; Lam-B1; lamB1; LamB1; Lambeta; laminin; Lan B1; LanB; lanB1; LM-B1/beta; LMbeta1; mspl
    Orthologs
    all
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    Genomic context

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    See LanB1 in Genome Data Viewer
    Location:
    28C4-28D1; 2-28 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7811438..7820771)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7811438..7820771)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Homocysteine-induced endoplasmic reticulum protein Neighboring gene r2d2 Neighboring gene Cell division cycle 14 Neighboring gene antisense RNA:CR45008 Neighboring gene uncharacterized protein Neighboring gene Receptor of activated protein kinase C 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Laminin Levels Regulate Tissue Migration and Anterior-Posterior Polarity during Egg Morphogenesis in Drosophila. Díaz de la Loza MC, et al. Cell Rep, 2017 Jul 5. PMID 28683315, Free PMC Article
    2. Distinct domains in the matricellular protein Lonely heart are crucial for cardiac extracellular matrix formation and heart function in Drosophila. Rotstein B, et al. J Biol Chem, 2018 May 18. PMID 29599288, Free PMC Article
    3. Distinct functions of the laminin β LN domain and collagen IV during cardiac extracellular matrix formation and stabilization of alary muscle attachments revealed by EMS mutagenesis in Drosophila. Hollfelder D, et al. BMC Dev Biol, 2014 Jun 17. PMID 24935095, Free PMC Article
    4. miRNA-based buffering of the cobblestone-lissencephaly-associated extracellular matrix receptor dystroglycan via its alternative 3'-UTR. Yatsenko AS, et al. Nat Commun, 2014 Sep 18. PMID 25232965, Free PMC Article
    5. Drosophila laminins act as key regulators of basement membrane assembly and morphogenesis. Urbano JM, et al. Development, 2009 Dec. PMID 19906841, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Laminin regulates follicle cell migration and anterior-posterior polarity during egg production.
      Title: Laminin Levels Regulate Tissue Migration and Anterior-Posterior Polarity during Egg Morphogenesis in Drosophila.
    2. Data show that laminin beta and collagen IV alpha1 were involved in cardiac and muscular abnormalities.
      Title: Distinct functions of the laminin β LN domain and collagen IV during cardiac extracellular matrix formation and stabilization of alary muscle attachments revealed by EMS mutagenesis in Drosophila.
    3. elimination of LanB1 prevents the normal morphogenesis of most organs and tissues, including the gut, trachea, muscles and nervous system
      Title: Drosophila laminins act as key regulators of basement membrane assembly and morphogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in basement membrane assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in substrate adhesion-dependent cell spreading IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of laminin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    LanB1
    Names
    CG7123-PA
    CG7123-PB
    LamininB1
    LanB1-PA
    LanB1-PB
    laminin
    laminin B1
    laminin B1 subunit
    laminin beta
    laminin beta-chain
    laminin beta1
    lamininB
    misplaced gonads

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7811438..7820771
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057270.5 → NP_476618.1  LanB1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476618.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0D8, P11046, Q26328, Q6AWM6, Q8SWY0, Q9VLW6, Q9XZT4
      Related
      FBpp0079113
      Conserved Domains (7) summary
      smart00180
      Location:789 → 834
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      COG3853
      Location:1439 → 1782
      TelA; Uncharacterized conserved protein YaaN involved in tellurite resistance [Defense mechanisms]
      cd00055
      Location:477 → 526
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:1094 → 1142
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:63 → 286
      Laminin_N; Laminin N-terminal (Domain VI)
      cl19764
      Location:1212 → 1398
      COG6; Conserved oligomeric complex COG6
      cl21509
      Location:1545 → 1702
      ApoLp-III_like; Apolipophorin-III and similar insect proteins

    2. NM_164773.3 → NP_723319.1  LanB1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723319.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0D8, P11046, Q26328, Q6AWM6, Q8SWY0, Q9VLW6, Q9XZT4
      Related
      FBpp0079114
      Conserved Domains (7) summary
      smart00180
      Location:789 → 834
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      COG3853
      Location:1439 → 1782
      TelA; Uncharacterized conserved protein YaaN involved in tellurite resistance [Defense mechanisms]
      cd00055
      Location:477 → 526
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:1094 → 1142
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:63 → 286
      Laminin_N; Laminin N-terminal (Domain VI)
      cl19764
      Location:1212 → 1398
      COG6; Conserved oligomeric complex COG6
      cl21509
      Location:1545 → 1702
      ApoLp-III_like; Apolipophorin-III and similar insect proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P11046.4 P11046

    Gene LinkOut

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