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    GM130 Golgi matrix protein 130 kD [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37524, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GM130provided by FlyBase
    Official Full Name
    Golgi matrix protein 130 kDprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034697
    Locus tag
    Dmel_CG11061
    See related
    AllianceGenome:FB:FBgn0034697
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11061; dgm130; dGM130; Dmel\CG11061; GM-130
    Summary
    Enables small GTPase binding activity. Involved in Golgi organization and positive regulation of dendrite morphogenesis. Located in Golgi cis cisterna and endoplasmic reticulum. Is expressed in several structures, including embryonic/larval salivary gland body; eye disc anterior to the morphogenetic furrow; follicle cell; germline cell; and gut section. Orthologous to several human genes including GOLGA2 (golgin A2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GM130 in Genome Data Viewer
    Location:
    58B10-58B10; 2-98 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22124567..22127502, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18012072..18015007, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Verprolin 1 Neighboring gene uncharacterized protein Neighboring gene meiotic from via Salaria 332 Neighboring gene uncharacterized protein Neighboring gene NtR Neighboring gene uncharacterized protein Neighboring gene arc

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A distinct Golgi-targeting mechanism of dGM130 in Drosophila neurons. Cheng G, et al. Front Mol Neurosci, 2023. PMID 37333614, Free PMC Article
    2. Distribution and morphological changes of the Golgi apparatus during Drosophila spermatogenesis. Yasuno Y, et al. Dev Growth Differ, 2013 Aug. PMID 23855356
    3. Centrosome localization determines neuronal polarity. de Anda FC, et al. Nature, 2005 Aug 4. PMID 16079847
    4. The multiple facets of the Golgi reassembly stacking proteins. Vinke FP, et al. Biochem J, 2011 Feb 1. PMID 21235525
    5. Individual carboxypeptidase D domains have both redundant and unique functions in Drosophila development and behavior. Sidyelyeva G, et al. Cell Mol Life Sci, 2010 Sep. PMID 20386952, Free PMC Article

    See all (103) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in Golgi vesicle transport IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in positive regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi cis cisterna IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi cis cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Golgi cisterna membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi stack IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cis-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    golgi matrix protein 130 kD
    Names
    CG11061-PA
    GM130-PA
    dGM130
    golgi matrix protein 130 kD ortholog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22124567..22127502 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137798.4 → NP_611642.2  golgi matrix protein 130 kD [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611642.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NFP0, Q9W289
      Related
      FBpp0071703
      Conserved Domains (1) summary
      pfam15070
      Location:261 → 725
      GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IGK8 Q8IGK8
    Q960J1 Q960J1
    Q9NFP0 Q9NFP0
    Q9W289 Q9W289

    Gene LinkOut

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