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    Lim1 LIM homeobox 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31813, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lim1provided by FlyBase
    Official Full Name
    LIM homeobox 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0026411
    Locus tag
    Dmel_CG11354
    See related
    AllianceGenome:FB:FBgn0026411
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH04929; CG10760; CG11354; dlim-1; dlim1; dLim1; Dlim1; Dmel\CG11354; Lim; lim1; LIM1
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in compound eye development; leg disc development; and regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including antennal lobe projection neuron vPN; embryonic head segment; embryonic/larval motor neurons; ganglia; and imaginal disc. Orthologous to human LHX1 (LIM homeobox 1) and LHX5 (LIM homeobox 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Lim1 in Genome Data Viewer
    Location:
    8A5-8B2; 1-25 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8756539..8805804, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8650572..8699837, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43297 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45537 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two distinct functions of Lim1 in the Drosophila antenna. Dolezal DM, et al. MicroPubl Biol, 2024. PMID 38957438, Free PMC Article
    2. Lola regulates Drosophila olfactory projection neuron identity and targeting specificity. Spletter ML, et al. Neural Dev, 2007 Jul 16. PMID 17634136, Free PMC Article
    3. Beadex, the Drosophila LIM only protein, is required for the growth of the larval neuromuscular junction. Chitre K, et al. J Neurophysiol, 2024 Aug 1. PMID 38838299
    4. Notch regulates the generation of diverse cell types from the lateral lineage of Drosophila antennal lobe. Das A, et al. J Neurogenet, 2010 Mar. PMID 20148759
    5. Requirements of Lim1, a Drosophila LIM-homeobox gene, for normal leg and antennal development. Tsuji T, et al. Development, 2000 Oct. PMID 11003832

    See all (98) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Beadex, the Drosophila LIM only protein, is required for the growth of the larval neuromuscular junction.
      Title: Beadex, the Drosophila LIM only protein, is required for the growth of the larval neuromuscular junction.
    2. During antennal development, expression of the selector genes Lim1 and Dll was sharply segregated. Notch signaling induces actomyosin-dependent apical constriction and epithelial fold. Disruption of Notch signaling or the actomyosin network reduces apical constriction and epithelial fold.
      Title: Notch-dependent epithelial fold determines boundary formation between developmental fields in the Drosophila antenna.
    3. Data show that Arrowhead and Lim1 act redundantly, using Chip as a co-factor, to prevent retinal differentiation in regions of the eye disc destined to become ventral head tissue.
      Title: The transcriptional co-factor Chip acts with LIM-homeodomain proteins to set the boundary of the eye field in Drosophila.
    4. homeodomain proteins Bar and Aristaless and the LIM-HOM proteins Apterous and Lim1 regulate distal leg development
      Title: Chip-mediated partnerships of the homeodomain proteins Bar and Aristaless with the LIM-HOM proteins Apterous and Lim1 regulate distal leg development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in compound eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived leg morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in leg disc proximal/distal pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    LIM homeobox 1
    Names
    CG11354-PA
    CG11354-PB
    Lim kinase
    Lim1-PA
    Lim1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      8756539..8805804 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272429.2 → NP_001259358.1  LIM homeobox 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259358.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PJE4
      Conserved Domains (2) summary
      COG5576
      Location:27 → 166
      COG5576; Homeodomain-containing transcription factor [Transcription]
      pfam00046
      Location:92 → 145
      Homeobox; Homeobox domain

    2. NM_132277.3 → NP_572505.1  LIM homeobox 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572505.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V472, Q9W3B9
      Related
      FBpp0071216
      Conserved Domains (4) summary
      cd09367
      Location:27 → 78
      LIM1_Lhx1_Lhx5; The first LIM domain of Lhx1 (also known as Lim1) and Lhx5
      cd09375
      Location:86 → 141
      LIM2_Lhx1_Lhx5; The second LIM domain of Lhx1 (also known as Lim1) and Lhx5
      COG5576
      Location:185 → 324
      COG5576; Homeodomain-containing transcription factor [Transcription]
      pfam00046
      Location:250 → 303
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PJE4 M9PJE4
    Q9V472 Q9V472

    Gene LinkOut

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