TfIIS RNA polymerase II elongation factor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: TfIISprovided by FlyBase
Official Full Name: RNA polymerase II elongation factorprovided by FlyBase
Primary source: FLYBASE:FBgn0010422
Locus tag: Dmel_CG3710
See related: AllianceGenome:FB:FBgn0010422
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BG:DS00929.12; br52; CG3710; Dmel\CG3710; DmS-II; DmSII; IIS; l(2)35cF; l(2)35Cf; l(2)br52; l35Cf; RnpSII; TFIIS; TFIISA; TFS-II
Summary: Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II and transcription elongation by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including adult head; central brain primordium; embryonic/larval midgut; embryonic/larval midgut primordium; and ganglia. Orthologous to human TCEA1 (transcription elongation factor A1); TCEA2 (transcription elongation factor A2); and TCEA3 (transcription elongation factor A3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (15058919..15060757, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (15058919..15060757, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

TFIIS is critical for efficient release of Pol II from the hsp70 promoter region
Title: Efficient release from promoter-proximal stall sites requires transcript cleavage factor TFIIS.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription elongation by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in transcription elongation by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

Names: CG3710-PA; CG3710-PB; TfIIS-PA; TfIIS-PB; lethal(2)35Cf; transcription cleavage factor IIS

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The following sections contain reference sequences that belong to a specific genome build. Explain