U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Uros1 Uroporphyrinogen III synthase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31817, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Uros1provided by FlyBase
    Official Full Name
    Uroporphyrinogen III synthase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0030066
    Locus tag
    Dmel_CG1885
    See related
    AllianceGenome:FB:FBgn0030066
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1885; Dmel\CG1885
    Summary
    Predicted to enable uroporphyrinogen-III synthase activity. Predicted to be involved in uroporphyrinogen III biosynthetic process. Predicted to be active in cytosol. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in cutaneous porphyria. Orthologous to human UROS (uroporphyrinogen III synthase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Uros1 in Genome Data Viewer
    Location:
    8B6-8B6; 1-25 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8898554..8900264, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8792587..8794297, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Moesin Neighboring gene RNA-binding motif protein 13 Neighboring gene enhancer of rudimentary

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Joint estimates of quantitative trait locus effect and frequency using synthetic recombinant populations of Drosophila melanogaster. Macdonald SJ, et al. Genetics, 2007 Jun. PMID 17435224, Free PMC Article
    2. Identification and characterization of a heme exporter from the MRP family in Drosophila melanogaster. Wang Z, et al. BMC Biol, 2022 Jun 2. PMID 35655259, Free PMC Article
    3. Genomic organization of gypsy chromatin insulators in Drosophila melanogaster. Ramos E, et al. Genetics, 2006 Apr. PMID 16452134, Free PMC Article
    4. The soluble proteome of the Drosophila antenna. Anholt RR, et al. Chem Senses, 2010 Jan. PMID 19917591, Free PMC Article
    5. Development of a Clickable Probe for Profiling of Protein Glutathionylation in the Central Cellular Metabolism of E. coli and Drosophila. Feng S, et al. Chem Biol, 2015 Nov 19. PMID 26526100

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables uroporphyrinogen-III synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables uroporphyrinogen-III synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uroporphyrinogen-III synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in uroporphyrinogen III biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in uroporphyrinogen III biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in uroporphyrinogen III biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    uroporphyrinogen III synthase 1
    Names
    CG1885-PA
    CG1885-PB
    Uros1-PA
    Uros1-PB
    NP_001259362.1
    NP_572507.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      8898554..8900264 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272433.1 → NP_001259362.1  uroporphyrinogen III synthase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259362.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A9YK67, Q9W3B3
      Conserved Domains (1) summary
      pfam02602
      Location:20 → 251
      HEM4; Uroporphyrinogen-III synthase HemD

    2. NM_132279.4 → NP_572507.1  uroporphyrinogen III synthase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572507.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A9YK67, Q9W3B3
      Related
      FBpp0071211
      Conserved Domains (1) summary
      pfam02602
      Location:20 → 251
      HEM4; Uroporphyrinogen-III synthase HemD
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W3B3 Q9W3B3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous