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    CG11593 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38477, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG11593provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035488
    Locus tag
    Dmel_CG11593
    See related
    AllianceGenome:FB:FBgn0035488
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey64; Dmel\CG11593
    Summary
    Predicted to be active in cytoplasm. Is expressed in central brain primordium; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium. Human ortholog(s) of this gene implicated in Cayman type cerebellar ataxia and cerebellar ataxia. Orthologous to several human genes including ATCAY (ATCAY kinesin light chain interacting caytaxin) and BNIP2 (BCL2 interacting protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG11593 in Genome Data Viewer
    Location:
    64A4-64A4; 3-10 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4037523..4040482, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4037523..4040482, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Gustatory receptor 64c Neighboring gene Gustatory receptor 64b Neighboring gene antisense RNA:CR45042 Neighboring gene Gustatory receptor 64d Neighboring gene Gustatory receptor 64e Neighboring gene Gustatory receptor 64f Neighboring gene Reduction in Cnn dots 5 Neighboring gene Dpy-30-like 2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gustatory and metabolic perception of nutrient stress in Drosophila. Linford NJ, et al. Proc Natl Acad Sci U S A, 2015 Feb 24. PMID 25675472, Free PMC Article
    2. Sugar receptors in Drosophila. Slone J, et al. Curr Biol, 2007 Oct 23. PMID 17919910, Free PMC Article
    3. Drosophila Gr64e mediates fatty acid sensing via the phospholipase C pathway. Kim H, et al. PLoS Genet, 2018 Feb. PMID 29420533, Free PMC Article
    4. Revealing posttranscriptional regulatory elements through network-level conservation. Chan CS, et al. PLoS Comput Biol, 2005 Dec. PMID 16355253, Free PMC Article
    5. Sunday Driver Mediates Multi-Compartment Golgi Outposts Defects Induced by Amyloid Precursor Protein. Du Q, et al. Front Neurosci, 2021. PMID 34140878, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG11593-PB
    CG11593-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4037523..4040482 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139594.2 → NP_647851.3  uncharacterized protein Dmel_CG11593, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647851.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A9UNE0, Q9VZJ4
      Conserved Domains (2) summary
      pfam12496
      Location:293 → 342
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:345 → 475
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    2. NM_001274463.1 → NP_001261392.1  uncharacterized protein Dmel_CG11593, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261392.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A9UNE0, Q9VZJ4
      Conserved Domains (2) summary
      pfam12496
      Location:293 → 342
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:345 → 475
      CRAL_TRIO_2; Divergent CRAL/TRIO domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VZJ4 Q9VZJ4

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