U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CG5504 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 48844, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CG5504provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002174
    Locus tag
    Dmel_CG5504
    See related
    AllianceGenome:FB:FBgn0002174
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cDNA 10D; Dmel\CG5504; DnaJ; l(2)701; l(2)tid; l(2)tud; lethal (2) tumorous imaginal discs; TID56
    Summary
    Enables patched binding activity. Involved in negative regulation of smoothened signaling pathway. Located in cytosol and mitochondrion. Is expressed in several structures, including adult head; embryonic Malpighian tubule tip cell; embryonic/larval midgut primordium; gut section; and larval muscle cell. Orthologous to human DNAJA3 (DnaJ heat shock protein family (Hsp40) member A3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CG5504 in Genome Data Viewer
    Location:
    59F6-59F6; 2-104 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23706913..23709026)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19594436..19596549)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L43 Neighboring gene salivary glands marred Neighboring gene lethal-(2)-denticleless Neighboring gene antisense RNA:CR45326 Neighboring gene ALG3, alpha-1,3- mannosyltransferase Neighboring gene uncharacterized protein Neighboring gene Sestrin Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Tumor suppression in Drosophila is causally related to the function of the lethal(2) tumorous imaginal discs gene, a dnaJ homolog. Kurzik-Dumke U, et al. Dev Genet, 1995. PMID 7758246
    2. Gene within gene configuration and expression of the Drosophila melanogaster genes lethal(2) neighbour of tid [l(2)not] and lethal(2) relative of tid[l(2)rot]. Kurzik-Dumke U, et al. Gene, 1997 Oct 24. PMID 9373138
    3. Mitochondrial localization and temporal expression of the Drosophila melanogaster DnaJ homologous tumor suppressor Tid50. Kurzik-Dumke U, et al. Cell Stress Chaperones, 1998 Mar. PMID 9585178, Free PMC Article
    4. Sequence of the new Drosophila melanogaster small heat-shock-related gene, lethal(2) essential for life [l(2)efl], at locus 59F4,5. Kurzik-Dumke U, et al. Gene, 1995 Mar 10. PMID 7890160
    5. Identification of a novel Drosophila melanogaster heat-shock gene, lethal(2)denticleless [l(2)dtl], coding for an 83-kDa protein. Kurzik-Dumke U, et al. Gene, 1996 Jun 1. PMID 8666267

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heat shock protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables patched binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of smoothened signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of smoothened signaling pathway IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to heat IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    uncharacterized protein
    Names
    CG5504-PA
    CG5504-PB
    CG5504-PC
    CG5504-PD
    CG5504-PE
    lethal (2) tumorous imaginal discs
    lethal(2) tumorous imaginal discs
    lethal(2)tumorous imaginal discs

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23706913..23709026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206209.3 → NP_995931.1  uncharacterized protein Dmel_CG5504, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995931.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D6W4V2, Q7KVH7
      Conserved Domains (4) summary
      cd10719
      Location:227 → 287
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:288 → 409
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      COG0484
      Location:63 → 437
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:65 → 127
      DnaJ; DnaJ domain

    2. NM_206210.3 → NP_995932.1  uncharacterized protein Dmel_CG5504, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995932.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O02528, O02529, O02549, Q24554, Q27237, Q27259, Q7KVH8, Q8T9A7, Q9W1K7
      UniProtKB/TrEMBL
      A0A0F7J3E9
      Conserved Domains (4) summary
      cd10719
      Location:227 → 287
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:288 → 409
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      COG0484
      Location:63 → 437
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:65 → 127
      DnaJ; DnaJ domain

    3. NM_080193.5 → NP_524932.2  uncharacterized protein Dmel_CG5504, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524932.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      D6W4V2
      Related
      FBpp0088498
      Conserved Domains (4) summary
      cd10719
      Location:227 → 287
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:288 → 409
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      COG0484
      Location:63 → 437
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:65 → 127
      DnaJ; DnaJ domain

    4. NM_001259554.2 → NP_001246483.1  uncharacterized protein Dmel_CG5504, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246483.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7M9, T2GGE7
      Conserved Domains (4) summary
      cd10719
      Location:227 → 287
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:288 → 409
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      COG0484
      Location:63 → 437
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:65 → 127
      DnaJ; DnaJ domain

    5. NM_001299848.1 → NP_001286777.1  uncharacterized protein Dmel_CG5504, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286777.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DN23, D6W4V2
      Conserved Domains (4) summary
      cd10719
      Location:227 → 287
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:288 → 409
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      COG0484
      Location:63 → 437
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:65 → 127
      DnaJ; DnaJ domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K7M9 A0A0B4K7M9
    D3DN23 D3DN23
    Q27237.2 Q27237
    Q7KVH7 Q7KVH7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools