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    Polr1E RNA polymerase I subunit E [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42201, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Polr1Eprovided by FlyBase
    Official Full Name
    RNA polymerase I subunit Eprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038601
    Locus tag
    Dmel_CG18600
    See related
    AllianceGenome:FB:FBgn0038601
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:CK01205; CG18600; CK01205; Dmel\CG18600; RPA49
    Summary
    Predicted to enable DNA binding activity. Predicted to be involved in RNA polymerase I preinitiation complex assembly and transcription elongation by RNA polymerase I. Predicted to be part of RNA polymerase I complex. Is expressed in several structures, including antennal anlage; anterior endoderm; anterior endoderm anlage; central brain anlage; and embryonic/larval midgut primordium. Orthologous to human POLR1E (RNA polymerase I subunit E). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Polr1E in Genome Data Viewer
    Location:
    91A2-91A2; 3-63 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18300195..18301728, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14125917..14127450, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene lethal (3) 05822 Neighboring gene Dynein light chain 90F Neighboring gene uncharacterized protein Neighboring gene Protein Kinase D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. dtctex-1, the Drosophila melanogaster homolog of a putative murine t-complex distorter encoding a dynein light chain, is required for production of functional sperm. Caggese C, et al. Mol Genet Genomics, 2001 May. PMID 11405626
    2. The Drosophila tctex-1 light chain is dispensable for essential cytoplasmic dynein functions but is required during spermatid differentiation. Li MG, et al. Mol Biol Cell, 2004 Jul. PMID 15090621, Free PMC Article
    3. PNUTS/PP1 regulates RNAPII-mediated gene expression and is necessary for developmental growth. Ciurciu A, et al. PLoS Genet, 2013 Oct. PMID 24204300, Free PMC Article
    4. In silico identification of Drosophila melanogaster genes encoding RNA polymerase subunits. Marygold SJ, et al. MicroPubl Biol, 2020 Oct 20. PMID 33274328, Free PMC Article
    5. Functional genomics identifies TOR-regulated genes that control growth and division. Guertin DA, et al. Curr Biol, 2006 May 23. PMID 16713952

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA polymerase I preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription elongation by RNA polymerase I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA polymerase I subunit E
    Names
    CG18600-PA
    Polr1E-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      18300195..18301728 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142451.3 → NP_650708.1  RNA polymerase I subunit E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650708.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VE94
      Related
      FBpp0083015
      Conserved Domains (1) summary
      pfam06870
      Location:33 → 379
      RNA_pol_I_A49; A49-like RNA polymerase I associated factor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VE94 Q9VE94

    Gene LinkOut

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