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    Tdc1 Tyrosine decarboxylase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35573, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tdc1provided by FlyBase
    Official Full Name
    Tyrosine decarboxylase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0259977
    Locus tag
    Dmel_CG30445
    See related
    AllianceGenome:FB:FBgn0259977
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG30445; CG3686; Dmel\CG30445; dTdc1; tdc; Tdc; TDC; tdc1
    Summary
    Predicted to enable tyrosine decarboxylase activity. Involved in behavioral response to ethanol. Predicted to be active in cytoplasm. Is expressed in several structures, including embryonic epipharynx; embryonic hypopharynx; foregut primordium; gut section; and sensory cluster. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Tdc1 in Genome Data Viewer
    Location:
    42C4-42C4; 2-55 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6677001..6680391, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2564506..2567896, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Heparan sulfate C5-epimerase Neighboring gene Post-GPI attachment to proteins 3 Neighboring gene uncharacterized protein Neighboring gene Ribonuclease P/MRP subunit p25 Neighboring gene long non-coding RNA:CR44164 Neighboring gene antisense RNA:CR44165 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isoform- and cell-specific function of tyrosine decarboxylase in the Drosophila Malpighian tubule. Blumenthal EM. J Exp Biol, 2009 Dec. PMID 19915121
    2. TfAP-2 is required for night sleep in Drosophila. Kucherenko MM, et al. BMC Neurosci, 2016 Nov 9. PMID 27829368, Free PMC Article
    3. [Some regularities in the genetic control of the stress reaction in Drosophila]. Raushenbakh IIu, et al. Genetika, 2001 Jan. PMID 11234428
    4. Effects of 20-hydroxyecdysone and juvenile hormone on octopamine metabolism in females of Drosophila. Bogomolova EV, et al. Arch Insect Biochem Physiol, 2009 Apr. PMID 19278013
    5. Trace amines differentially regulate adult locomotor activity, cocaine sensitivity, and female fertility in Drosophila melanogaster. Hardie SL, et al. Dev Neurobiol, 2007 Sep 1. PMID 17638385

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Synthesis of tyramine by Tdc1 in the principal cells of the Malpighian tubule is required for physiological responses to tyrosine.
      Title: Isoform- and cell-specific function of tyrosine decarboxylase in the Drosophila Malpighian tubule.
    2. dTdc1 and dTdc2 are functional but noncomplementing Drosophila tyrosine decarboxylase genes: dTdc1 is expressed nonneurally, whereas dTdc2 is expressed neurally
      Title: Two functional but noncomplementing Drosophila tyrosine decarboxylase genes: distinct roles for neural tyramine and octopamine in female fertility.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carboxy-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tyrosine decarboxylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in behavioral response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine decarboxylase 1
    Names
    CG30445-PA
    Tdc1-PA
    tdc1
    tyramine decarboxylase 1
    tyrosine decarboxylase
    NP_610226.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6677001..6680391 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136382.3 → NP_610226.2  tyrosine decarboxylase 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610226.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6N2, Q8MZ32
      Related
      FBpp0085476
      Conserved Domains (1) summary
      pfam00282
      Location:35 → 412
      Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z6N2 A1Z6N2
    Q8MZ32 Q8MZ32

    Gene LinkOut

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