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    Ptp61F Protein tyrosine phosphatase 61F [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38160, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ptp61Fprovided by FlyBase
    Official Full Name
    Protein tyrosine phosphatase 61Fprovided by FlyBase
    Primary source
    FLYBASE:FBgn0267487
    Locus tag
    Dmel_CG9181
    See related
    AllianceGenome:FB:FBgn0267487
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.297; anon-WO0140519.98; BEST:LP01280; CG9178; CG9181; CPtp62A; DCPTP62A; Dmel\CG9181; dptp61F; dPTP61F; DPTP61F; Ptp-61F; PTP1b; PTP1B; ptp61F; Ptp61f; PTP61F; R-PTP 61F
    Summary
    Enables non-membrane spanning protein tyrosine phosphatase activity and protein sequestering activity. Involved in several processes, including cellular response to mechanical stimulus; germ-band extension; and negative regulation of signal transduction. Located in mitochondrial envelope; nucleus; and perinuclear region of cytoplasm. Is expressed in several structures, including Malpighian tubule primordium; adult head; central brain primordium; male germline cell; and somatic cell of testis. Used to study intestinal cancer. Human ortholog(s) of this gene implicated in coronary artery disease; essential hypertension; and type 2 diabetes mellitus. Orthologous to several human genes including PTPN2 (protein tyrosine phosphatase non-receptor type 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Ptp61F in Genome Data Viewer
    Location:
    61F7-62A2; 3-0.5 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1342493..1475257, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1342493..1475257, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Hydroxymethylbilane synthase Neighboring gene indra Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Glutamic acid-CTC 3-1 Neighboring gene transfer RNA:Glutamic acid-CTC 3-2 Neighboring gene transfer RNA:Glutamic acid-CTC 3-3 Neighboring gene transfer RNA:Glutamic acid-CTC 3-4 Neighboring gene transfer RNA:Glutamic acid-CTC 3-5 Neighboring gene transfer RNA:Glutamic acid-CTC 3-6 Neighboring gene transfer RNA:Glutamic acid-CTC 3-7 Neighboring gene roughoid Neighboring gene transfer RNA:Glutamic acid-CTC 3-8 Neighboring gene transfer RNA:Glutamic acid-CTC 3-9 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene alpha1,3-fucosyltransferase D Neighboring gene uncharacterized protein Neighboring gene Stromalin 2 Neighboring gene long non-coding RNA:CR44842 Neighboring gene small non-coding RNA:CR43701 Neighboring gene rhomboid Neighboring gene N(alpha)-acetyltransferase 30 B Neighboring gene robl62A Neighboring gene stem cell tumor

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in axon guidance PubMed 
    involved_in cellular response to hypoxia PubMed 
    involved_in cellular response to mechanical stimulus PubMed 
    involved_in germ-band extension PubMed 
    involved_in mitotic cell cycle PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade  
    involved_in negative regulation of ERK1 and ERK2 cascade PubMed 
    involved_in negative regulation of JNK cascade PubMed 
    involved_in negative regulation of TORC1 signaling PubMed 
    involved_in negative regulation of cell population proliferation PubMed 
    involved_in negative regulation of epidermal growth factor receptor signaling pathway PubMed 
    involved_in negative regulation of insulin receptor signaling pathway PubMed 
    involved_in negative regulation of insulin receptor signaling pathway PubMed 
    involved_in negative regulation of organ growth PubMed 
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    involved_in negative regulation of receptor signaling pathway via JAK-STAT  
    involved_in negative regulation of receptor signaling pathway via JAK-STAT PubMed 
    involved_in negative regulation of receptor signaling pathway via JAK-STAT PubMed 
    involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway PubMed 
    involved_in positive regulation of hippo signaling PubMed 
    involved_in protein dephosphorylation  
    involved_in regulation of protein localization PubMed 
    involved_in regulation of protein stability PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in mitochondrial envelope PubMed 
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in perinuclear region of cytoplasm PubMed 

    General protein information

    Preferred Names
    protein tyrosine phosphatase 61F
    Names
    CG9181-PA
    CG9181-PB
    CG9181-PC
    CG9181-PD
    CG9181-PE
    Ptp61F-PA
    Ptp61F-PB
    Ptp61F-PC
    Ptp61F-PD
    Ptp61F-PE
    cytoplasmic protein tyrosine phosphatase 62A
    protein tyrosine phosphatase
    protein-tyrosine-phosphatase
    NP_001261253.1
    NP_476687.1
    NP_476688.1
    NP_728600.1
    NP_728601.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1342493..1475257 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167874.2 → NP_728600.1  protein tyrosine phosphatase 61F, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728600.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMI1
      Related
      FBpp0072600
      Conserved Domains (2) summary
      smart00194
      Location:30 → 290
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:57 → 290
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    2. NM_057340.4 → NP_476688.1  protein tyrosine phosphatase 61F, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476688.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMI1
      Related
      FBpp0072601
      Conserved Domains (2) summary
      smart00194
      Location:34 → 295
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:62 → 295
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    3. NM_001274324.2 → NP_001261253.1  protein tyrosine phosphatase 61F, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261253.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B8A420, Q8IRH4
      Conserved Domains (2) summary
      smart00194
      Location:1 → 178
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:1 → 178
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    4. NM_167875.2 → NP_728601.1  protein tyrosine phosphatase 61F, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728601.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B8A420, Q8IRH4
      Related
      FBpp0072603
      Conserved Domains (2) summary
      smart00194
      Location:1 → 178
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:1 → 178
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    5. NM_057339.5 → NP_476687.1  protein tyrosine phosphatase 61F, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476687.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27932, Q8SZY3, Q9W0G1, Q9W0G2
      UniProtKB/TrEMBL
      D3DMI1, I0B1P6
      Related
      FBpp0072602
      Conserved Domains (2) summary
      smart00194
      Location:34 → 295
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:62 → 295
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
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