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    Dis3l2 Dis3 like 3'-5' exoribonuclease 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38034, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dis3l2provided by FlyBase
    Official Full Name
    Dis3 like 3'-5' exoribonuclease 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0035111
    Locus tag
    Dmel_CG16940
    See related
    AllianceGenome:FB:FBgn0035111
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG16940; dis3L2; Dis3L2; dmdis3l2; dmDis3l2; Dmel\CG16940
    Summary
    Enables 3'-5'-RNA exonuclease activity. Involved in miRNA catabolic process and tRNA decay. Located in cytoplasm. Is expressed in adult head and organism. Used to study Perlman syndrome. Human ortholog(s) of this gene implicated in Perlman syndrome and nephroblastoma. Orthologous to human DIS3L2 (DIS3 like 3'-5' exoribonuclease 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dis3l2 in Genome Data Viewer
    Location:
    61B2-61B2; 3-1 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (212709..216479)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (212709..216479)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Pre-mRNA processing factor 4 kinase Neighboring gene thoc7 Neighboring gene pseudo Neighboring gene Kaz1-ORFB Neighboring gene uncharacterized protein Neighboring gene pyrexia

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of a TUTase/RNase complex required for Drosophila gametogenesis. Lin CJ, et al. RNA, 2017 Mar. PMID 27974621, Free PMC Article
    2. Dis3L2 regulates cell proliferation and tissue growth through a conserved mechanism. Towler BP, et al. PLoS Genet, 2020 Dec. PMID 33370287, Free PMC Article
    3. Molecular basis for cytoplasmic RNA surveillance by uridylation-triggered decay in Drosophila. Reimão-Pinto MM, et al. EMBO J, 2016 Nov 15. PMID 27729457, Free PMC Article
    4. A novel role for the 3'-5' exoribonuclease Dis3L2 in controlling cell proliferation and tissue growth. Towler BP, et al. RNA Biol, 2016 Dec. PMID 27630034, Free PMC Article
    5. In vivo functional characterization of the SARS-Coronavirus 3a protein in Drosophila. Wong SL, et al. Biochem Biophys Res Commun, 2005 Nov 18. PMID 16212942, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dis3L2 regulates cell proliferation and tissue growth through a conserved mechanism.
      Title: Dis3L2 regulates cell proliferation and tissue growth through a conserved mechanism.
    2. Study describes a role for Dis3L2 in the proliferation of imaginal disc cells during Drosophila development through expression regulation of a discrete set of transcripts including a mRNA encoding a cation channel.
      Title: A novel role for the 3'-5' exoribonuclease Dis3L2 in controlling cell proliferation and tissue growth.
    3. The mutants of Tailor and Dis3L2 are viable and lack overt morphological defects. Instead, these mutants exhibit defects in female and male fertility, implying specific requirements in the germline.
      Title: Characterization of a TUTase/RNase complex required for Drosophila gametogenesis.
    4. Here, the authors show that in flies, 3' terminal RNA uridylation triggers the processive, 3'-to-5' exoribonucleolytic decay via the RNase II/R enzyme CG16940, a homolog of the human Perlman syndrome exoribonuclease Dis3l2.
      Title: Molecular basis for cytoplasmic RNA surveillance by uridylation-triggered decay in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-5'-RNA exonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in miRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in miRNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Dis3 like 3'-5' exoribonuclease 2
    Names
    CG16940-PA
    CG16940-PC
    Dis3l2-PA
    Dis3l2-PC
    NP_612012.1
    NP_728490.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      212709..216479
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138168.3 → NP_612012.1  Dis3 like 3'-5' exoribonuclease 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612012.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6AWL1, Q95TN0, Q9W0T7
      Related
      FBpp0072389
      Conserved Domains (2) summary
      COG0557
      Location:408 → 974
      VacB; Exoribonuclease R [Transcription]
      pfam00773
      Location:548 → 897
      RNB; RNB domain

    2. NM_167805.2 → NP_728490.1  Dis3 like 3'-5' exoribonuclease 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728490.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6AWL1, Q8IRJ7
      Related
      FBpp0072388
      Conserved Domains (2) summary
      COG0557
      Location:420 → 986
      VacB; Exoribonuclease R [Transcription]
      pfam00773
      Location:560 → 909
      RNB; RNB domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IRJ7 Q8IRJ7
    Q9W0T7 Q9W0T7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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