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    CG8858 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36319, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8858provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033698
    Locus tag
    Dmel_CG8858
    See related
    AllianceGenome:FB:FBgn0033698
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8858
    Summary
    Predicted to enable molecular adaptor activity. Predicted to be involved in ERAD pathway. Predicted to be part of proteasome complex. Predicted to be active in cytoplasm and nucleus. Is expressed in adult head and spermatozoon. Orthologous to human ECPAS (Ecm29 proteasome adaptor and scaffold). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8858 in Genome Data Viewer
    Location:
    48E8-48E8; 2-66 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12192374..12198854, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8079879..8086359, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Small ribonucleoprotein particle protein SmF Neighboring gene Cytochrome P450 6g1 Neighboring gene Cytochrome P450 6g2 Neighboring gene Cytochrome P450 6t3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ribosomal protein S11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DDT resistance in Drosophila correlates with Cyp6g1 over-expression and confers cross-resistance to the neonicotinoid imidacloprid. Daborn P, et al. Mol Genet Genomics, 2001 Dec. PMID 11810226
    2. Interspecies analysis of MYC targets identifies tRNA synthetases as mediators of growth and survival in MYC-overexpressing cells. Zirin J, et al. Proc Natl Acad Sci U S A, 2019 Jul 16. PMID 31262815, Free PMC Article
    3. Metallophosphoesterase regulates light-induced rhodopsin endocytosis by promoting an association between arrestin and the adaptor protein AP2. Mu Y, et al. J Biol Chem, 2019 Aug 30. PMID 31324721, Free PMC Article
    4. Nuclear receptor DHR4 controls the timing of steroid hormone pulses during Drosophila development. Ou Q, et al. PLoS Biol, 2011 Sep. PMID 21980261, Free PMC Article
    5. C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles. Lee KH, et al. Cell, 2016 Oct 20. PMID 27768896, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of proteasome complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8858-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12192374..12198854 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136902.3 → NP_610746.1  uncharacterized protein Dmel_CG8858 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610746.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K1A6, Q9V677
      Related
      FBpp0087116
      Conserved Domains (2) summary
      pfam13001
      Location:20 → 504
      Ecm29; Proteasome stabilizer
      sd00044
      Location:1502 → 1535
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V677.1 Q9V677

    Gene LinkOut

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